Cincinnati Reds vs Chicago Cubs Prediction – 8/6/2025

The Cincinnati Reds will visit the Chicago Cubs for the final game of a three-game series on Wednesday afternoon. The Reds have won the first two games of this series on the road and can complete a sweep with a win here. But Chicago is the favorite to salvage this game at home. Continue reading to get my analysis for this game, including my Reds vs Cubs prediction.

Our Reds vs Cubs Pick

  • Pick: Cincinnati Reds to win
  • Confidence: 4 stars
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Game Snapshot

  • Matchup: Cincinnati Reds vs Chicago Cubs
  • Date & Time: Wednesday, August 6, 2025, 2:20 PM EDT
  • Starting Pitchers: Andrew Abbott (Reds) vs Cade Horton (Cubs)
  • Stadium: Wrigley Field, Chicago, IL
  • Broadcast: MLB.tv

Key Storylines

Pitching Matchup

Andrew Abbott has been a standout pitcher for the Reds. He has an impressive 8-1 record with a 2.15 ERA in 2025. Abbott has a 2.30 ERA over five career starts against the Cubs and will look for another good outing against Chicago here. Abbott will go up against Cade Horton. Horton is currently riding a 17.2-inning scoreless streak with a 1.26 ERA in his past five outings. Abbott will be challenged by a very good opposing pitcher and we’ll see how he responds to that pressure.

Key Players

  • Elly De La Cruz (Reds): De La Cruz has been instrumental in the Reds’ lineup thanks to his power and speed.
  • Spencer Steer (Reds): The Reds got a home run and four RBI from Steer in their win on Tuesday over the Cubs.
  • Pete Crow-Armstrong (Cubs): Crow-Armstrong has been exceptional this season. He leads the Cubs with 27 home runs for the year.
  • Matt Shaw (Cubs): Shaw hit a home run from the ninth spot in the Cubs’ order on Tuesday. More production from him would be huge.

Recent Team Streaks

The Reds have won two straight games and three of their last four. Chicago has lost two straight games and has lost three of their last four. Cincinnati will look to keep both of those runs going and Chicago will look to buck those trends.

Best Player Props

PlayerProp
Andrew AbbottOver 5.5 strikeouts
Cade HortonUnder 2.5 earned runs allowed
Elly De La CruzOver 0.5 stolen bases
Pete Crow-ArmstrongOver 0.5 home runs
  • The season series between these teams is tied 4-4 heading into Wednesday afternoon.
  • The under is 2-0 in the current series between these teams.
  • The Reds are 27-24 in day games this season. Chicago is 30-23 in the daytime.

Reds vs Cubs Model Projection

  • Score Projection: Reds 5 – Cubs 4
  • Win Probability: Reds 50%, Cubs 50%

Final Thoughts

Andrew Abbott is one of the most underrated pitchers in all of baseball. I expect him to keep his excellent season going and for the Cubs to struggle to match his production on the mound. I will take the Reds as an underdog as I think Abbott makes this game a coin flip at worst for Cincinnati.


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Home MLB Picks Cincinnati Reds vs Chicago Cubs Prediction – 8/6/2025