Cincinnati Reds vs Athletics Pick – 9/12/2025

The Cincinnati Reds and the Athletics will open a three-game series on Friday night in Sacramento. These are two clubs in very different positions in the late portion of the regular season. The Reds are still hanging around in the NL Wild Card race and the A’s are just trying to finish out their season respectably. Here, I break down this matchup and bring you my Reds vs Athletics prediction for this interleague series opener.

Our Reds vs Athletics Pick

  • Pick: Reds moneyline
  • Confidence: 3/5
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Game Snapshot

  • Matchup: Cincinnati Reds vs Athletics
  • Date & Time: Friday, September 12, 10:05 PM ET
  • Starting Pitchers: Brady Singer vs JT Ginn
  • Stadium: Sutter Health Park, West Sacramento, CA
  • Broadcast: MLB.tv

Key Storylines

  • The Reds are 1.5 games back of the final Wild Card spot in the National League. Cincinnati is a slight underdog in this game and they need to stack up wins over a team like the A’s to give themselves a chance of moving into a playoff spot.
  • The Athletics have not played well in Sacramento this season. The A’s are 30-42 in home games this season and they have not responded well to their temporary home while they get things sorted out for their eventual move to Las Vegas.

Pitching matchup

The Reds will start Brady Singer in this matchup. Singer is 13-9 on the season and has a 3.98 ERA. He should give the Reds a good chance to win this game and help their Wild Card chances significantly. Singer will be opposed by JT Ginn of the Athletics to begin this game. Ginn is 3-6 on the year and has a 4.95 ERA. Ginn pitched well in his last start, giving up one run in five innings in a win over the Angels. But he went 0-4 in six starts in August before that and will try to continue moving in the right direction.

Recent team streaks

  • The Reds have won two straight games and four of their last five games going into tonight.
  • The Athletics won their most recent game but have dropped three of their last four outings.

Best Player Props

PlayerProp TypePick
Elly De La CruzTotal BasesOver 1.5
Brady SingerStrikeoutsOver 5.5
Brent RookerTotal BasesOver 1.5
  • This is the first matchup between these teams this season.
  • Cincinnati is 26-19 against American League opponents this year.
  • The Marlins are 21-21 in interleague games in 2025.

Reds vs Athletics Model Projection

Score Projection: Reds 5 – Athletics 4

Win Probability: Reds 56%, Athletics 44%

Final Thoughts

The Reds should be able to win this game despite the line being close to a pick ’em at this point. Cincinnati has the starting pitching advantage going into this game and their offense is more consistent than that of the A’s. I’ll take Cincinnati to get the win and to continue to put pressure on the teams ahead of them in the NL Wild Card race.


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Home MLB Picks Cincinnati Reds vs Athletics Pick – 9/12/2025