The Chicago White Sox and Pittsburgh Pirates will meet for the second game of their three-game series on Saturday afternoon. The White Sox enjoyed a dominant 10-1 win in the opening game of this series. Pittsburgh will look to even things up with a win today but will have to get the better of a strong starting pitcher on the other side to do that. Here, I break down this game in the betting markets and make my White Sox vs Pirates prediction.
Our White Sox vs Pirates Pick
- Pick: Pirates Moneyline
- Confidence: ★★★★☆
- Bonus Bets For This Game: Use bet365 promo code ATSBONUS to bet $5 and get $150 in bonus bets, win or lose, for this MLB matchup!
Game Snapshot
- Matchup: Chicago White Sox @ Pittsburgh Pirates
- Date & Time: Saturday, July 19, 2025, 6:40 p.m. ET
- Starting Pitchers: Mike Burrows vs Adrian Houser
- Stadium: PNC Park, Pittsburgh, PA
- Broadcast: SportsNet PT and CHSN
White Sox vs Pirates Odds
| Moneyline | Total |
|---|---|
| White Sox +112 | Over 8.5 (-103) |
| Pirates -137 | Under 8.5 (-118) |
Key Storylines
Pitching Form
- Mike Burrows: The rookie righty has a 1-3 record and a 4.83 ERA. He averages over a strikeout per inning but also gives up over a hit per inning.
- Adrian Houser: Houser has been one of the few bright spots for the White Sox during another dismal season for them. In four of his five wins, he’s held opponents under two runs. His last start included seven innings and just one run allowed.
Bullpen Usage
- The Pirates’ bullpen is coming off a taxing game on Friday where they helped to allow 10 runs to Chicago.
- The White Sox don’t typically have a strong bullpen. But their pen got off to a strong start in this series on Friday and they will look to build on that here.
Recent Team Streaks
- Pirates: The Pirates are 1–4 over their last five games. They’ve scored under five runs in all five of those outings.
- White Sox: The White Sox have gone 2-3 in their last five games.
Best Player Props
| Player | Prop |
|---|---|
| Oneil Cruz (PIT) | Over 0.5 Home Runs |
| Adrian Houser (CWS) | Over 6.5 Strikeouts |
| Andrew Benintendi (CWS) | Over 1.5 Total Bases |
Betting Trends & H2H
- The White Sox lead the season series between these teams 1-0.
- Pittsburgh has allowed their opponents to score in double-digits in two of their last three games.
White Sox vs Pirates Model Projection
- Score Projection: Pittsburgh 5 – Chicago 3
- Win Probability: Pirates 55%, White Sox 45%
Final Thoughts
Houser is definitely the better starting pitcher going into this game. That should benefit the White Sox. But I’m still not ready to trust this White Sox team on the road. Chicago is 12-36 away from home going into this matchup. I’ll back the Pirates to bounce back from their loss to the White Sox and to even this three-game set heading into Sunday’s rubber match.
