Chicago White Sox vs Kansas City Royals Pick – 8/16/2025

The Chicago White Sox will take on the Kansas City Royals at Kauffman Stadium in Kansas City on Saturday. The Royals won the opening game of this weekend series by shutting down the bats of the White Sox. Can they do it again? I attempt to answer that question here with my White Sox vs Royals prediction for Saturday night.

Our White Sox vs Royals Pick

  • Pick: Over 9.5
  • Confidence: ★★★★☆
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Game Snapshot

  • Matchup: Chicago White Sox vs Kansas City Royals
  • Date & Time: Saturday, August 16, 2025, 7:10 p.m. ET
  • Starting Pitchers: Michael Lorenzen (KC) vs Sean Burke (CWS)
  • Stadium: Kauffman Stadium, Kansas City, MO
  • Broadcast: FDSKC and CHSN

Key Storylines

Pitching matchup

Michael Lorenzen takes the mound for Kansas City against Sean Burke for Chicago. Both pitchers have ERAs over 4.00 for the season and will look to take advantage of facing an opponent that doesn’t have a winning record in this matchup.

Key Players

  • Salvador Perez hit a go-ahead home run for the Royals in the fourth inning of yesterday’s win over the White Sox.
  • Lenyn Sosa hit a home run to give the White Sox their only run of Friday’s game. He will need to be productive at the plate again to help his team win this contest.

Recent team streaks

  • The White Sox have lost two games in a row and three of their last four.
  • Kansas City has won three of its last four games to get back to the .500 mark for the season.

Best Player Props

PlayerProp
Vinnie Pasquantino (KC)Over 1.5 Total Bases
Lenyn Sosa (CWS)Over 1.5 Total Bases
  • The Royals lead the season series 6-2 over the White Sox.
  • Kansas City has won two straight games over the White Sox entering Saturday’s matchup.
  • The first game of this three-game series went under the total.

White Sox vs Royals Model Projection

Score Projection: Royals 6 – White Sox 4

Win Probability: Royals 59%, White Sox 41%

Final Thoughts

I think we will see a little more scoring from these teams than we saw in the first game of this three-game set. Both teams are sending slightly worse starting pitchers to the mound from what we saw yesterday. That should help this game to be a little more high-scoring. I recommend betting the over at 9.5 runs as we should see some power on display on both sides here.


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Home MLB Picks Chicago White Sox vs Kansas City Royals Pick – 8/16/2025