Chicago White Sox vs Detroit Tigers Pick – 9/6/2025
Detroit returns home Saturday for Game 2 of this three-game set with Chicago. Tigers ace Tarik Skubal gets the ball against veteran lefty Martín Pérez. Detroit has handled this series across the season and is protecting a division lead, while Chicago arrives hotter than it has been all year after a sweep of the Twins. Current prices lean heavily to Detroit and you can get my White Sox vs Tigers prediction for this contest below.
Our White Sox vs Tigers Pick
- Pick: Tigers -1.5
- Confidence: 4/5
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Game Snapshot
- Matchup: Chicago White Sox vs Detroit Tigers
- Date & Time: Saturday, September 6, 6:10 p.m. ET
- Starting Pitchers: Martín Pérez vs Tarik Skubal
- Stadium: Comerica Park, Detroit, MI
- Broadcast: FDSDET and CHSN
Key Storylines
- Detroit’s ace Tarik Skubal carries elite 2025 numbers, including a microscopic ERA, 200-plus strikeouts, and a sub-1.00 WHIP, placing him at the front of AL Cy Young chatter again.
- Chicago enters this series on a genuine upswing after a four-game sweep of the Twins and a win in this series opener on Friday.
- Splits matter: Detroit has been one of MLB’s top offenses versus left-handed pitching this season. Chicago’s offense has lagged across the board, but especially against righties.
Pitching matchup
- Tarik Skubal, LHP, Detroit: 12-4, 2.18 ERA, 216 K, 0.87 WHIP. Recent history against Chicago is excellent, with five wins and a 2.17 ERA over his last five appearances against the White Sox.
- Martín Pérez, LHP, Chicago: 1-3, 2.16 ERA across 41.2 innings, including a strong debut and a quality road start in Detroit in April.
Recent team streaks
- The White Sox have won six games in a row entering this matchup on Saturday.
- Detroit has lost three of its last four games heading into this matchup.
Best Player Props
| Player | Market | Recommendation |
|---|---|---|
| Tarik Skubal | Strikeouts | Over 7.5 |
| Riley Greene | Total Bases | Over 1.5 |
| Kerry Carpenter | Home Run | Yes |
| Lenyn Sosa | Total Bases | Over 1.5 |
Betting Trends & H2H
| Angle | Chicago White Sox | Detroit Tigers |
|---|---|---|
| Last 5 head-to-head results | Won 3 of last 5 vs DET | Won 2 of last 5 vs CHW |
| Home/Road Record | 24-46 Away | 45-28 Home |
White Sox vs Tigers Model Projection
Score Projection: White Sox 3, Tigers 5
Win Probability: White Sox 38%, Tigers 62%
Final Thoughts
Detroit owns a substantial edge on the hill any time Tarik Skubal starts, and its lineup has graded highly versus left-handed pitching, while Chicago’s surge meets a different tier of starter than it saw in Minneapolis. I’m backing the Tigers -1.5 in this game. If you prefer totals, a lean Under 8.5 fits Skubal’s profile and Chicago’s uneven offense against quality pitching.
