Chicago White Sox vs Cleveland Guardians Prediction – 9/14/2025

Sunday brings a late-season divisional tilt with playoff implications as the Chicago White Sox visit the Cleveland Guardians at Progressive Field. Cleveland enters September 14 needing every win to keep pace in the American League wild-card race, while Chicago arrives trending upward after an excellent two-week surge that has injected life into an offense that lagged for much of the summer. Here, I take a closer look at this AL Central matchup and give you my White Sox vs Guardians prediction.

Our White Sox vs Guardians Pick

• Pick: Guardians -1.5
• Confidence: 3/5
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Game Snapshot

• Matchup: Chicago White Sox vs Cleveland Guardians
• Date and Time: Sunday, September 14, 1:40 pm Eastern
• Starting Pitchers: Yoendrys Gómez vs Slade Cecconi
• Stadium: Progressive Field, Cleveland, OH
• Broadcast: Guardians TV and CHSN

Key Storylines

• The Guardians are still hanging around in the AL Wild Card race. They are three games back of the Seattle Mariners in the race for the final playoff spot in the AL. A win here would be huge for the Guardians given everything they have to play for.
• The White Sox have had a nightmare of a season but have at least shown signs of life over the last couple of weeks. They need six wins down the stretch to avoid 100 losses for the year.
• Probable arms: Chicago hands the ball to Yoendrys Gómez, who brings swing-and-miss but spotty command. Cleveland counters an inconsistent starter of their own in Slade Cecconi.

Pitching matchup

• Yoendrys Gómez, RHP, White Sox: 3-2, 5.05 ERA, 1.51 WHIP across 46.1 innings. His slider can miss bats, though walks have elevated his pitch counts and limited the length he can provide.
• Slade Cecconi, RHP, Guardians: 6-6, 4.45 ERA, 1.25 WHIP over 115.1 innings. Cecconi has not been great by any means this season. But his pitching has been more than serviceable to the Guardians, who are looking to stay in the Wild Card hunt as the regular season draws closer to an end.

Recent team streaks

• The White Sox have lost two games in a row coming into the final game of this series.
• Cleveland has won three straight games and four of their last five.

Best Player Props

Betting Trends & H2H

• Cleveland holds a 10-2 lead in their season series with the White Sox.
• This is the last game of the regular-season series between these teams.
• The White Sox have scored just one run over the first two games of this series.

White Sox vs Guardians Model Projection

• Score Projection: White Sox 3 – Guardians 5
• Win Probability: White Sox 41%, Guardians 59%

Final Thoughts

Pricing reflects Cleveland’s bullpen strength, situational defense, and a more reliable run-prevention baseline at Progressive Field. The White Sox have struggled at the plate in this series so far and I expect that to cootninue in this game. I’ll take Cleveland to win and cover the runline at home.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.