Chicago Cubs vs St. Louis Cardinals Pick – 8/8/2025
One of the biggest rivalries in baseball will be renewed on Friday night as the Chicago Cubs visit the St. Louis Cardinals at Busch Stadium. Both of these teams are fighting for Wild Card spots in the National League at this stage of the season. They will each look to help their Wild Card chances at the expense of their rivals with a win here. Before first pitch from St. Louis, you can find my Cubs vs Cardinals prediction below.
Our Cubs vs Cardinals Pick
- Pick: Chicago Cubs -1.5
- Confidence: 4 out of 5
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Game Snapshot
- Matchup: Chicago Cubs vs St. Louis Cardinals
- Date & Time: Friday, August 8, 2025, at 8:15 p.m. ET
- Starting Pitchers:
- Cubs – Matthew Boyd (11‑4, 2.34 ERA)
- Cardinals – Michael McGreevy (3‑2, 5.08 ERA)
- Stadium: Busch Stadium, St. Louis, MO
- Broadcast: MLB Network
Key Storylines
Pitching matchup
Matthew Boyd enters with an 11‑4 record and a 2.34 ERA. He’s clearly the staff ace right now and will hope for some help after he got stuck with a no-decision in his last start despite throwing seven shutout innings. Michael McGreevy enters this game with a 5.08 ERA for the Cardinals and will look to step up to help his team in this rivalry game.
Key Players
- Nico Hoerner (Cubs): Hoerner has solid season-long numbers (.292 BA, .340 OBP, .380 SLG). He leads the Cubs in batting average and will look to get on-base as often as possible tonight.
- Willson Contreras (Cardinals): Contreras supplies the power for the Cardinals lineup. He leads the team in home runs and RBI going into this game.
Recent Team Streaks
- Cubs: The Cubs are 2-3 over their last five games. They snapped a two-game losing streak with a win over the Cincinnati Reds to close out their series on Wednesday.
- Cardinals: The Cardinals took two out of three games against the Los Angeles Dodgers in their last series and will try to build on that encouraging showing in this series opener.
Best Player Props
| Player | Prop |
|---|---|
| Nico Hoerner | Over 1.5 Total Bases |
| Seiya Suzuki | Over 0.5 Home Runs |
| Matthew Boyd | Over 6.5 Strikeouts |
Betting Trends & H2H
- The Cubs lead the season series 4-3 over the Cardinals.
- Chicago has won four of the last five games in this rivalry matchup.
- These teams are 2-2 against each other at Busch Stadium this year.
- Chicago is 30-26 on the road for the season.
- St. Louis is 32-24 in their home games.
Cubs vs Cardinals Model Projection
Score Projection: Cubs 5 – Cardinals 3
Win Probability: Cubs 65%, Cardinals 35%
Final Thoughts
Chicago has a huge advantage in the starting pitching department going into this game. I think that and a more dangerous offense will help Chicago to win this game and cover the runline as a favorite. Look for Chicago to reward Boyd for a strong start this time around instead of saddling him with a no-decision.
