Chicago Cubs vs St. Louis Cardinals Pick – 8/10/2025

The Chicago Cubs will aim to complete a series win against the St. Louis Cardinals on Sunday night at Busch Stadium. This game is the Sunday Night Baseball matchup for this week and both teams will look to impress on the big stage. Before these NL Central rivals do battle, continue reading to get my Cubs vs Cardinals prediction.

Cubs vs Cardinals Pick

• Pick: Cubs to win
• Confidence: ★★★★☆
• MLB Bonus Bets For Sunday: Hit the Claim Bonus button below to claim our exclusive DraftKings bonus code. You can bet $5 and get $200 in bonus bets INSTANTLY, plus over $200 off NFL Sunday Ticket!

Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket

+ Parlay Profit Boosts All Season Long!

Gambling Problem? Call or TEXT 1-800-Gambler 21+

+ Parlay Profit Boosts All Season Long!

Gambling Problem? Call or TEXT 1-800-Gambler 21+

Click To Claim

Claim Bonus
Promo Code: Click To Claim

Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket

+ Parlay Profit Boosts All Season Long!

Gambling Problem? Call or TEXT 1-800-Gambler 21+

Click To Claim

Claim Bonus
Promo Code: Click To Claim

Claim Bonus
Promo Code: Click To Claim

Gambling Problem? Call or TEXT 1-800-Gambler 21+

Game Snapshot

• Matchup: Chicago Cubs vs. St. Louis Cardinals
• Date & Time: Sunday, August 10, 2025, 7:10 PM ET
• Starting Pitchers: Shōta Imanaga (Cubs) vs. Sonny Gray (Cardinals)
• Stadium: Busch Stadium, St. Louis, MO
• Broadcast: ESPN

Key Storylines

Pitching Matchup

• Shōta Imanaga (Cubs): The left-handed pitcher boasts an impressive 8-4 record with a 3.12 ERA and a 1.00 WHIP. His command has been exceptional with only 17 walks allowed in 89.1 innings. Imanaga’s consistency on the mound has been a significant factor in the Cubs’ recent success.
• Sonny Gray (Cardinals): Gray enters the game with a 10-5 record and a 4.21 ERA. His strikeout numbers are better than those of Imanaga and Chicago will have to be disciplined and wait him out in this contest.

Key Players

• Cubs: Seiya Suzuki leads the Cubs with 27 home runs and 84 RBI. Nico Hoerner contributes with a .289 batting average and consistency at the top of the order.
• Cardinals: Willson Contreras remains a key offensive threat with 16 home runs and 65 RBI. The absence of All-Star second baseman Brendan Donovan due to a groin issue may impact the Cardinals’ offensive depth.

Recent Team Streaks

• Cubs: The Cubs have won two of their last three games coming into this series finale in St. Louis.
• Cardinals: The Cardinals had a two-game winning streak snapped by the Cubs on Saturday. They have won three out of their last five games overall.

Best Player Props

Betting Trends & H2H

• The Cubs took the lead in the season series between these teams by a 5-4 margin on Saturday.
• The first two games of this series have gone 1-1 in the over/under market.
• St. Louis is 33-25 at home this year and can get over the .500 mark with a win.

Cubs vs Cardinals Model Projection

• Score Projection: Cubs 5 – Cardinals 4
• Win Probability: Cubs 55%, Cardinals 45%

Final Thoughts

It is tempting to take the Cardinals to win at home to get back above the .500 mark for the year. But the Cubs just have too big an advantage in the starting pitching department with Imanaga. I recommend taking the Cubbies in this game as they look to keep up with the surging Milwaukee Brewers in the NL Central race.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.