Chicago Cubs vs Los Angeles Angels Prediction – 8/23/2025
The Chicago Cubs will face the Los Angeles Angels on Saturday night at Angel Stadium in Anaheim. The Cubs lead the three-game series 1-0 after a 3-2 victory in Friday’s opener. Chicago is in contention for a postseason spot while the Angels are on the outside looking in. Here, I have broken this game down and you can find my Cubs vs Angels prediction below.
Our Cubs vs Angels Pick
- Pick: Cubs Moneyline
- Confidence: 4/5
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Game Snapshot
- Matchup: Chicago Cubs vs Los Angeles Angels
- Date & Time: Saturday, August 23, 2025, 9:38 PM EDT
- Starting Pitchers: Cade Horton (Cubs) vs Victor Mederos (Angels)
- Stadium: Angel Stadium, Anaheim, CA
- Broadcast: FDSW, MARQ
Key Storylines
Pitching Matchup
Cade Horton has been a reliable arm for the Cubs at 7-4 with a 3.08 ERA. His performance has been instrumental in Chicago’s success this season. Los Angeles’ Victor Mederos is 0-1 with a 5.54 ERA and is still finding his footing in the majors with a high WHIP in 2025. This disparity on the mound gives the Cubs a significant advantage.
Key Players
- Pete Crow-Armstrong and Kyle Tucker both hit home runs in the first game of this series for the Cubs and they will both be keys to the Cubs’ success here as well.
- Yoan Moncada had a huge game for the Angels in Friday’s loss. He knocked in the Angels’ only runs in that game and will look for more production here.
Recent Team Streaks
- Chicago has won four of its last five games coming into this interleague contest.
- The Angels have lost three of their last four games coming into this series opener.
Best Player Props
| Player | Prop Category | Prediction |
|---|---|---|
| Pete Crow-Armstrong | Home Runs | Over 0.5 |
| Taylor Ward | Total Bases | Over 1.5 |
| Cade Horton | Strikeouts | Over 5.5 |
Betting Trends & H2H
- The Cubs lead the season series between these teams 1-0 after Friday’s series opener.
- There were five total runs scored on Friday night and these teams combined to stay under the total.
- The Angels are 70-57 on the runline this season. They rank sixth in runline win percentage for the year.
Cubs vs Angels Model Projection
- Score Projection: Cubs 6 – Angels 5
- Win Probability: Cubs 51%, Angels 49%
Final Thoughts
The Cubs are the superior team both with their starting pitching and with their offense in this game. There is always the chance that the Angels can pull off the upset in this game given how unpredictable baseball is. But I think Horton will pitch well for the Cubs and that Chicago will get their second win in a row over Los Angeles when all is said and done in Anaheim.
