Chicago Cubs vs Los Angeles Angels Prediction – 8/22/2025
The Chicago Cubs are set to face the Los Angeles Angels on Friday night at Angel Stadium in Anaheim. The Cubs have an uphill climb if they want to catch up in the NL Central standings but they are in a great position to grab a Wild Card spot. They will look for a win to help them move closer to postseason baseball tonight. Before the Cubs and Angels do battle in Anaheim, keep reading to get my Cubs vs Angels prediction for tonight.
Our Cubs vs Angels Pick
- Pick: Angels Moneyline
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Chicago Cubs vs Los Angeles Angels
- Date & Time: Friday, August 22, 2025, 9:38 p.m. ET
- Starting Pitchers: Undecided (CHC) vs Tyler Anderson (LAA)
- Stadium: Angel Stadium, Anaheim, CA
- Broadcast: Marquee Sports Network, FanDuel Sports Network West
Key Storylines
Pitching Matchup
The Cubs have yet to announce their starting pitcher for this game. Who they end up going with could have a big impact on the outcome of this matchup. The Angels are expected to send left-hander Tyler Anderson to the mound. Anderson is 2-8 and has a 4.77 ERA this year. Anderson has struggled this season and the Cubs’ offense will look to capitalize on his inconsistency.
Key Players
The Cubs’ bullpen will be the key group of players in this game. They are likely going to have to contribute a lot in this contest with the Cubs not knowing who their starting pitcher is going to be. They could even go with an opener out of the bullpen and throw all nine innings with relief arms.
Recent Team Streaks
- The Cubs won three out of five games against the Milwaukee Brewers this week. They had a three-game winning streak snapped by the Brewers in the final game of that series.
- The Angels lost two out of three games against the Cincinnati Reds in their most recent series.
Best Player Props
| Player | Prop |
|---|---|
| Seiya Suzuki | Over 0.5 Home Runs |
| Taylor Ward | Over 0.5 Home Runs |
| Tyler Anderson | Over 4.5 Strikeouts |
Betting Trends & H2H
- This is the first game of the season series between the Cubs and Angels this year.
- The Cubs are 32-30 on the road for the year.
- The Angels are 34-32 at home during the 2025 MLB season.
Cubs vs Angels Model Projection
- Score Projection: Angels 5 – Cubs 3
- Win Probability: Angels 59%, Cubs 41%
Final Thoughts
This is obviously not an easy game to handicap without knowing who the starting pitcher is going to be for the Cubs. But assuming the player they do tap to start doesn’t throw a gem, the Angels have a decent shot to win this game. I’ll take the Angels to win on the moneyline, though I’d urge bettors to wait to find out who the starter is going to be for Chicago before making any decisions.
