Chicago Cubs vs Chicago White Sox Prediction – 7/27/2025

The Chicago Cubs look to grab a series win over the Chicago White Sox on Sunday afternoon at Rate Field. The Cubs evened this three-game set at a game apiece with a 6–1 victory on Saturday. The Cubs are favored to win the rubber match today against a struggling White Sox team. Here, I break down this interleague contest and give you my Cubs vs White Sox prediction.

Our Cubs vs White Sox Pick

  • Pick: Chicago Cubs -1.5
  • Confidence: ★★★★☆
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Game Snapshot

  • Matchup: Chicago Cubs vs Chicago White Sox
  • Date & Time: Sunday, July 27, 2025, at 2:10 PM ET
  • Starting Pitchers: Ben Brown (Cubs) vs Sean Burke (White Sox)
  • Stadium: Rate Field, Chicago
  • Broadcast: CHSN (White Sox), MARQ (Cubs)

Key Storylines

Pitching Matchup

Ben Brown enters this game with a 6.48 ERA and a 4–7 record. He has shown flashes of potential despite his high ERA. He will look to take advantage of the offensive struggles of the White Sox. Sean Burke has a 4.19 ERA and a 4–8 record. He has been inconsistent this season. He could give the Cubs’ lineup an opportunity to exploit his weaknesses.

Key Players

  • Chicago Cubs: Pete Crow-Armstrong leads the team with 27 home runs and he has 74 RBI. Seiya Suzuki has also been a consistent contributor with 81 RBI.
  • Chicago White Sox: Luis Robert Jr. has 10 home runs and 41 RBIs for the White Sox. Miguel Vargas has 12 home runs and 41 RBI. Both will need to step up for the White Sox to have a chance in this game.

Recent Team Streaks

  • Chicago Cubs: The Cubs have gone 2-3 in their last five games.
  • Chicago White Sox: The White Sox are 3-2 in their last five games. They had a two-game winning streak snapped by the Cubs yesterday.

Best Player Props

PlayerProp
Pete Crow-ArmstrongOver 0.5 Home Runs
Seiya SuzukiOver 1.5 RBIs
Luis Robert Jr.Over 0.5 Home Runs
  • The Cubs lead the season series 4-1 over the White Sox.
  • This is the last game set to be played between these teams this season.
  • The White Sox have scored in double-digits in two of their last three games.

Cubs vs White Sox Model Projection

  • Score Projection: Cubs 6 – White Sox 3
  • Win Probability: Cubs 57.37%, White Sox 42.63%

Final Thoughts

The winner of each game in this series has won by two runs or more. I expect that trend to continue in this contest, as the Cubs should win this game by two runs or more. I’ll lay the runline with Chicago here, as their power bats should take advantage of the issues with the White Sox pitching staff.


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Home MLB Picks Chicago Cubs vs Chicago White Sox Prediction – 7/27/2025