Chicago Cubs vs Chicago White Sox Prediction – 7/25/2025
The Chicago Cubs and Chicago White Sox will open a crosstown rivalry series on Friday night at Rate Field. The Cubs have had a much better season than the White Sox so far in 2025. But the records can be thrown out the window in rivalry matchups like this one. Here, I break down this game from a betting perspective and give you my Cubs vs White Sox prediction for tonight.
Our Cubs vs White Sox Pick
- Pick: Under 8.5
- Confidence: 4 stars
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Game Snapshot
- Matchup: Chicago Cubs vs. Chicago White Sox
- Date & Time: Friday, July 25, 2025, 7:40 PM ET
- Starting Pitchers: Shota Imanaga (Cubs) vs. Adrian Houser (White Sox)
- Stadium: Rate Field, Chicago, IL
- Broadcast: CHSN and MARQ
Key Storylines
- Pitching Form: Shota Imanaga enters the game with a 7-3 record and a 2.40 ERA. He has been electric for the Cubs when healthy and will look to take advantage of a weak White Sox lineup. Adrian Houser has a 5-2 record and a 1.89 ERA. He has been just as impressive as Imanaga even if the team around him is much worse.
- Bullpen Usage: Both bullpens have had plenty of rest going into this game. Both teams had Thursday off. That should set their relief pitching up nicely to perform at or near its best in this game.
- Recent Team Streaks: The Cubs have lost three of their last four games coming into this rivalry matchup with the White Sox. The White Sox have won four of their last five games and are playing respectable baseball of late.
Best Player Props
| Player | Prop |
|---|---|
| Shota Imanaga | Over 6.5 strikeouts |
| Adrian Houser | Under 4.5 strikeouts |
| Pete Crow-Armstrong (Cubs) | Over 0.5 home runs |
| Miguel Vargas (White Sox) | Over 0.5 home runs |
Betting Trends & H2H
- The Cubs have a 3-0 lead in the season series against the White Sox. They swept the White Sox at Wrigley Field in mid-May.
- The Cubs outscored the White Sox 26-8 in those three games.
- The White Sox have covered the runline 57.3% of the time this season. That is the third-best runline win percentage in baseball.
Cubs vs White Sox Model Projection
- Score Projection: Cubs 4 – White Sox 3
- Win Probability: Cubs 54%, White Sox 46%
Final Thoughts
I think that the Cubs should win this game when all is said and done. But I think that the total is a more appealing play in this game. Both starting pitchers have been phenomenal this season. I think we will see that continue here, as Imanaga and Houser should lead us to a comfortable under in this game where regional bragging rights are on the line.
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