Chicago Cubs vs Atlanta Braves Pick – 9/10/2025

The Chicago Cubs and Atlanta Braves will wrap up their three-game series on Wednesday night. These teams have split the first two games of this series at Truist Park. Both teams more or less know where their season is going to end up over the next few weeks. The Cubs are headed for the playoffs and the Braves are heading home for October. But a series win is on the line here and you can continue reading to get our Cubs vs Braves prediction for Wednesday.

Our Cubs vs Braves Pick

  • Pick: Braves moneyline
  • Confidence: 3/5
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Game Snapshot

  • Matchup: Chicago Cubs vs Atlanta Braves
  • Date & Time: Wednesday, September 10, 2025, 7:15 p.m. ET
  • Starting Pitchers: Jameson Taillon vs Chris Sale
  • Stadium: Truist Park, Atlanta, GA
  • Broadcast: Marquee Sports Network in Chicago, FanDuel Sports South in Atlanta

Key Storylines

  • The Cubs responded to dropping the opening game of this series by winning 6-1 on the road on Tuesday. Getting a win in the rubber match would move the Cubs a step closer to clinching at least a Wild Card spot in the National League.
  • Atlanta has Chris Sale on the mound for this game. While Sale is not going to win a second straight NL Cy Young award this year, having him on the mound is a good thing for the Braves now that he is healthy again.

Pitching matchup

  • Chris Sale comes into this start at 5-4 with a 2.38 ERA. The lefty has paired elite strikeout rates with strong command. Chicago’s lineup is deeper in right-handed bats, but Sale’s slider-change combo has neutralized both sides this season. Sale has pitched well despite injuries cutting into his season.
  • The Cubs will go with Jameson Taillon to start this contest. Taillon is 9-6 with a 4.15 ERA this year. He has pitched well in his last two starts with two earned runs allowed across 11 innings. If he can keep that going, the Cubs could win a second straight on the road.

Recent team streaks

  • Chicago ended a three-game losing streak with their 6-1 win over Atlanta on Tuesday.
  • Atlanta has lost three of their last four games.

Best Player Props

Prop TypePlayerPick
StrikeoutsChris SaleOver 7.5
Total BasesMatt OlsonOver 1.5
Total BasesSeiya SuzukiUnder 1.5
Home RunPete Crow-ArmstrongOver 0.5
  • Chicago has a 3-2 lead in the season series against Atlanta.
  • This is the final game of the season series between these teams.

Cubs vs Braves Model Projection

Score Projection: Cubs 2 – Braves 4

Win Probability: Cubs 44%, Braves 56%

Final Thoughts

Chicago has been the better team throughout this season. But the Braves are in a much better spot in this game thanks to the presence of Chris Sale. I’ll take the Braves to win as a favorite here, though their play this season could lead me to regret that decision by the end of this contest.


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Home MLB Picks Chicago Cubs vs Atlanta Braves Pick – 9/10/2025