The Boston Red Sox and the Tampa Bay Rays will face off at George M. Steinbrenner Field on Saturday night. Boston (84-70) is jockeying for a Wild Card spot in the AL, while Tampa Bay (75-79) is already eliminated but looking to play spoiler in its final home series. The Red Sox enter having rattled off a big comeback win and the Rays will look to bounce back from that result. Before the first pitch from Tampa, continue reading to get my Red Sox vs Rays prediction for tonight.
Our Red Sox vs Rays Pick
- Pick: Rays moneyline
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Boston Red Sox vs Tampa Bay Rays
- Date & Time: Saturday, September 20, 2025, 7:05 PM ET
- Starting Pitchers: Kyle Harrison (Red Sox) vs Adrian Houser (Rays)
- Stadium: George M. Steinbrenner Field, Tampa Bay, FL
- Broadcast: FDSSUN and NESN
Key Storylines
Pitching matchup
Boston’s Kyle Harrison (1-1, 4.05 ERA) draws the start. This will be his second appearance with the Red Sox after he missed a few months of the season after spending some time in San Francisco. Tampa Bay counters with Adrian Houser (8-4, 3.11 ERA), who has performed quite well this year. The edge on paper goes to Houser based on experience and a lower ERA. But Boston’s offense can ruin the day of even the best starting pitchers at times.
Recent team streaks
- Boston has won three of its last five games. That includes the opening game of this series, which the Sox won 11-7.
- Tampa Bay had a two-game winning streak snapped with their loss to Boston on Friday night.
Best Player Props
| Player | Prop |
|---|---|
| Trevor Story | Over 0.5 home runs |
| Kyle Harrison | Under 4.5 strikeouts |
| Everson Pereira | Over 1.5 total bases |
Betting Trends & H2H
- Boston holds a 9-2 lead in the season series against Tampa Bay.
- The Sox have won seven straight meetings with the Rays going into this contest.
Red Sox vs Rays Model Projection
Score Projection: Tampa Bay Rays 5 – Boston Red Sox 4
Win Probability: Red Sox 48%, Rays 52%
Final Thoughts
Boston is the better team overall this season. But I think that the Rays will win at home tonight and put a dent in Boston’s Wild Card chances. Houser is a much better option on the mound than Harrison, who will probably only go a few innings for Boston tonight. Expect the strain on the Boston bullpen to cost them in this contest and for the Rays to get a win over their division rivals.
