Baltimore Orioles vs San Diego Padres Pick – 9/1/2025
The Baltimore Orioles and San Diego Padres will meet for the first time this season when they play in San Diego on Monday. San Diego needs to keep winning games to help their chances of winning the NL West this season. They will look to get an important win against an Orioles team that has struggled throughout this season. Before these teams begin their September, continue reading to get my Orioles vs Padres prediction from Petco Park.
Our Orioles vs Padres Pick
- Prediction: San Diego Padres Moneyline
- Confidence: ★★★★☆
- Get Your Bonus Bets: Click the Claim Bonus button to get our DraftKings Sportsbook promo – bet $5 and get $300 INSTANTLY and get over $200 off NFL Sunday Ticket!
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
Gambling Problem? Call or TEXT 1-800-Gambler 21+ 
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Promo Code: Click To Claim
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Promo Code: Click To Claim
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Game Snapshot
- Matchup: Baltimore Orioles at San Diego Padres
- Date & Time: Monday, September 1, 2025, 6:40 p.m. ET
- Starting Pitchers: Kyle Bradish (Orioles) vs Dylan Cease (Padres)
- Stadium: Petco Park, San Diego, CA
- Broadcast: SDPA and MASN2
Key Storylines
Pitching Matchup
Kyle Bradish will get the start for the Orioles after recently returning from Tommy John surgery. He allowed just two runs and struck out 10 batters in six innings in his return to the mound. Dylan Cease will take the mound for the Padres. He has a 6–11 record with a 4.82 ERA, a 1.33 WHIP, and an impressive 183 strikeouts over 142 innings.
Key Players
Star hitters like Fernando Tatis Jr., Manny Machado, Luis Arraez, and Ramón Laureano anchor the lineup for the Padres. Laureano enters the game riding a two-game hit streak and has 22 homers on the season. The Baltimore offense has struggled late in August. They will need hitters like Gunnar Henderson to step up if they want a win in this matchup.
Recent Team Streaks
The Orioles have lost four of their last five games and they lost their last series to the San Francisco Giants. The Padres dropped three of their last four games going into this series against the Orioles.
Best Player Props
| Player | Prop |
|---|---|
| Ramón Laureano | Over 0.5 Home Runs |
| Dylan Cease | Over 6.5 Strikeouts |
| Kyle Bradish | Under 5.5 Strikeouts |
Betting Trends & H2H
- This is the first game of the season series between these teams in 2025.
- These teams will play just three games this season. All of those games will come this week.
- Baltimore is 30-39 on the road this season.
- San Diego is 43-22 at home during the 2025 campaign.
Orioles vs Padres Model Projection
Score Projection: Padres 5 – Orioles 4
Win Probability: Padres 58%, Orioles 42%
Final Thoughts
This game should be a good one and the starting pitching matchup features two arms that can pile up the strikeouts. Timely hitting on each side will go a long way in determining who gets the win here. I think the lineup depth for the Padres gives them a better chance of getting the timely hits that they need to win here. San Diego is my best bet for this contest as they look to cut into their two-game deficit in the NL West standings.
