Baltimore Orioles vs Chicago White Sox Pick – 9/15/2025
The Baltimore Orioles and Chicago White Sox will open a three-game series at Rate Field in Chicago on Monday night. These teams are both out of playoff contention going into the final couple of weeks of the season. But someone has to win this matchup between American League opponents tonight. Here, I break down this game in the betting markets and give you my Orioles vs White Sox prediction for Monday’s action.
Our Orioles vs White Sox Pick
- Pick: Orioles -1.5
- Confidence: ★★★☆☆
- Get Your Bonus Bets: Use BetMGM promo code ATSBONUS to get up to $1,500 in bonus bets if your first bet doesn’t win!
Game Snapshot
- Teams: Baltimore Orioles vs Chicago White Sox
- Date & Time: Monday, September 15, 6:40 pm CT
- Starting Pitchers: Kyle Bradish vs Sean Burke
- Stadium: Guaranteed Rate Field, Chicago, IL
- Broadcast: CHSN, MASN
Key Storylines
Pitching Breakdown
Kyle Bradish is on the mound for the Orioles to start this game. Bradish is 0-1 on the season with a 2.65 ERA in just 17 innings of work. Bradish has averaged over a strikeout per inning since returning to action due to injuries. His ability to miss bats will be important against a White Sox offense that is known to struggle.
Sean Burke’s recent recall suggests he’s the likely starter Monday. His season numbers reflect uneven command. His fastball can touch 96–99, but walks and deep counts have shortened his outings. Baltimore’s lineup doesn’t walk a ton overall, yet its core punishes mistakes left up in the zone.
Recent team streaks
Both of these teams have lost three games in a row coming into today. The Orioles are 6-4 over their last 10 games and the White Sox are 5-5 over their last 10. Neither team has much of anything to play for in this contest other than pride.
Best Player Props
| Player | Prop | Pick |
|---|---|---|
| Gunnar Henderson | Total Bases | Over 1.5 |
| Jackson Holliday | Total Bases | Over 1.5 |
| Lenyn Sosa | Home Run | Over 0.5 |
| Gunnar Henderson | Home Run | Over 0.5 |
Betting Trends & H2H
- The Orioles lead the season series against the White Sox by a margin of 3-0.
- Chicago has failed to score more than two runs in a game against the Orioles so far this season.
- Baltimore is 33-42 in their road games for the season.
- Chicago is 32-43 in their home games in 2025.
Orioles vs White Sox Model Projection
Score Projection: Orioles 5 – White Sox 3
Win Probability: Orioles 63%, White Sox 37%
Final Thoughts
Kyle Bradish being back on the mound for the Orioles is a good thing both for Baltimore and for baseball fans. His strikeout volume has already been strong since his return and he could be even better as he continues to reacclimate himself on the mound. I think that Bradish will have another strong outing in this game and that he will propel the Orioles to a win on the road in this game. I’ll take the Orioles to win and cover the runline in Chicago to open this series.
