Athletics vs St. Louis Cardinals Prediction – 9/1/2025
The Athletics will travel to Busch Stadium on Monday to open a series against the St. Louis Cardinals. Both teams are below .500 for the season. Oddsmakers give the Cardinals a slight edge behind veteran Sonny Gray but neither of these teams has performed at a consistent level this year. Before this interleague series begins, continue reading to get my Athletics vs Cardinals prediction.
Our Athletics vs Cardinals Pick
- Pick: Cardinals Moneyline
- Confidence: 3/5
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Game Snapshot
- Matchup: Athletics vs St. Louis Cardinals
- Date & Time: Monday, September 1, 2025, 2:15 PM
- Starting Pitchers: Luis Morales (Athletics) vs Sonny Gray (Cardinals)
- Stadium: Busch Stadium, St. Louis, MO
- Broadcast: FD Sports Midwest, NBC Sports California
Key Storylines
- Athletics rookie Luis Morales has been sensational. He has allowed just three earned runs in his first 22.2 innings.
- Sonny Gray provides veteran stability for a Cardinals team clinging to slim Wild Card hopes.
- Both teams struggle with consistency at the plate. Both rank in the bottom third of MLB in OPS.
Pitching Matchup
Morales is a hard-throwing righty with a devastating slider and has yet to suffer a loss. He faces his toughest test yet against a patient Cardinals lineup. Gray has been steady and has struck out 148 batters in 153 innings while limiting hard contact. His veteran approach should give him an edge over the A’s young hitters.
Recent Team Streaks
- The A’s were swept over three games by the Texas Rangers in their last series going into this set of games.
- St. Louis had a three-game winning streak snapped on Sunday in a loss to the Cincinnati Reds.
Best Player Props
| Player | Prop |
|---|---|
| Alec Burleson | Over 1.5 Total Bases |
| Sonny Gray | Over 5.5 Strikeouts |
Betting Trends & H2H
- This is the first meeting between the Athletics and Cardinals this season.
- The Athletics are 15-24 in games against National League opponents so far this year.
- The Cardinals are 20-22 against teams from the American League in 2025.
Athletics vs Cardinals Model Projection
- Score Projection: Athletics 3 – Cardinals 5
- Win Probability: Athletics 42%, Cardinals 58%
Final Thoughts
The pitching duel between Luis Morales and Sonny Gray makes this a compelling Labor Day matinee. Morales’ electric stuff looks like it can silence any lineup. But the Cardinals’ experience and situational hitting give them the edge at home in my opinion. I’ll go with the Cardinals to get a win to open this series and for St. Louis to move to within one game of the .500 mark for the 2025 season.
