Athletics vs Minnesota Twins Prediction – 8/21/2025

The Athletics and Minnesota Twins will wrap up their three-game series on Thursday afternoon in Minneapolis. The A’s have won the first two games of this series and will look to secure the sweep with a win in this contest. These teams have an identical win total so far this year and the winner will end this series with a better record. Continue reading to get my Athletics vs Twins prediction for Thursday’s matinee.

Our Athletics vs Twins Pick

  • Prediction: Athletics Moneyline
  • Confidence: 3/5
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Game Snapshot

  • Matchup: Athletics vs Minnesota Twins
  • Date & Time: Thursday, August 21, 2025, 1:10 p.m. Eastern
  • Starting Pitchers: Jack Perkins vs Jose Urena
  • Stadium: Target Field, Minneapolis, MN
  • Broadcast: MLB.tv

Key Storylines

Pitching Matchup

The Athletics will hand the ball to Jack Perkins to start this game. Perkins has only started logging more than a few innings at a time in his outings. He has picked up the win in each of his last two starts and will look for another victory against the Twins. Jose Urena has been decent since being acquired by the Twins. He has a 2.13 ERA in his three appearances with Minnesota and will try to perform at a similar level against the A’s.

Key Players

Oakland’s offense got a huge home run from Shea Langeliers to win against the Twins on Wednesday. Langeliers hit a two-run home run in the top of the 10th inning and his power will be important in this contest as well. Minnesota’s Trevor Larnach drove in a run in a losing effort on Wednesday and has hit safely in six of his last seven games.

Recent Team Streaks

The Athletics have won two games in a row and four of their last five outings. The Twins have dropped two games in a row in this series and have lost four of their last five games coming into this series finale.

Best Player Props

PropPlayer
Over 0.5 Home RunsTyler Soderstrom (Athletics)
Under 4.5 StrikeoutsJose Urena (Twins)
Over 1.5 Total BasesBrent Rooker (Athletics)
  • The season series between these teams is tied 3-3 in 2025.
  • This is the final game of the regular season series scheduled between these teams.
  • Road teams are 5-1 in the season series between the A’s and Twins.
  • Every game between these teams has been settled by two or more runs.

Athletics vs Twins Model Projection

Score Projection: Athletics 5 – Twins 4
Win Probability: Athletics 53%, Twins 47%

Final Thoughts

Based on the reputations of these teams, you might think that the Twins would be well-positioned to beat the A’s at home. But the Athletics have put up a ton of fight in the second half of the season and are playing better baseball than the Twins right now. I recommend backing the A’s to win this game on the road and to complete a three-game sweep of Minnesota.


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Home MLB Picks Athletics vs Minnesota Twins Prediction – 8/21/2025