Athletics vs Boston Red Sox Prediction – 9/17/2025
The Athletics will take on the Boston Red Sox at Fenway Park on Wednesday night. The Red Sox have the better record between these teams but it is the A’s that are playing better baseball of late. Boston will look to bounce back from a series-opening loss to the Athletics and help their postseason chances by doing so. Before the first pitch from Boston, continue reading to get my Athletics vs Red Sox prediction for tonight.
Our Athletics vs Red Sox Pick
- Pick: Red Sox -1.5
- Confidence: 3/5
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Game Snapshot
- Matchup: Athletics vs Boston Red Sox
- Date & Time: Wednesday, September 17, 2025, 6:45 p.m. ET
- Starting Pitchers: Mason Barnett vs Lucas Giolito
- Stadium: Fenway Park, Boston, MA
- Broadcast: NESN, NBC Sports California
Key Storylines
- Oakland’s youth movement is performing at a high level of late. The A’s swept the Reds and won the first game of this series as well. They may be out of playoff contention, but the Athletics are playing with pride.
- Boston has been struggling of late but they are still 2.5 games clear in the race for the final AL Wild Card position. Boston would love a bounce-back performance after Tuesday’s loss to help their playoff prospects.
Pitching matchup
Mason Barnett has struggled over a small sample of innings for the Athletics. He is 1-1 with an 8.53 ERA in 12.2 innings of work. He has allowed 18 hits in those 12.2 innings and he needs to do a better job of keeping opponents off the bases if the A’s are going to have a chance to keep their current winning streak going.
Boston will give the start to Lucas Giolito tonight. Giolito has been solid for the Sox, going 10-4 with a 3.31 ERA on the year. He is giving up under a hit per inning on the season and has turned his career around nicely in Boston after a couple of rough seasons.
Recent team streaks
- The Athletics have won five games in a row and have won their last two games against Boston.
- Boston is 1-4 over its last five games and has allowed some other teams to stay close in the Wild Card hunt.
Best Player Props
| Player | Prop | Pick |
|---|---|---|
| Trevor Story | Total Bases | Over 1.5 |
| Brent Rooker | Home Run | Over 0.5 |
| Shea Langeliers | Total Bases | Over 1.5 |
| Lucas Giolito | Strikeouts | Over 5.5 |
Betting Trends & H2H
- The season series between these teams is tied 2-2.
- Road teams are 3-1 in matchups between the Athletics and Red Sox in 2025.
Athletics vs Red Sox Model Projection
Score Projection: Athletics 4 – Red Sox 6
Win Probability: Athletics 44%, Red Sox 56%
Final Thoughts
Boston has been struggling of late and the Athletics have had plenty to do with that. But I think that the Sox are going to turn things around tonight behind the solid pitching of Giolito. I will lay the runline with Boston in a great bounce back spot for the home team.
