Arizona Diamondbacks vs San Francisco Giants Prediction – 9/10/2025
The Arizona Diamondbacks and San Francisco Giants will wrap up a three-game series on Wednesday afternoon in the Bay Area. The Giants have won the first two games of this series and will look to complete an important sweep for their NL Wild Card hopes. Here, I break down the final game of this series and give you my Diamondbacks vs Giants prediction for this matchup.
Our Diamondbacks vs Giants Pick
- Pick: Giants moneyline
- Confidence: 3/5
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Game Snapshot
- Matchup: Arizona Diamondbacks vs San Francisco Giants
- Date & Time: Wednesday, September 10, 2025, 3:45 PM ET
- Starting Pitchers: Eduardo Rodriguez vs Carson Seymour
- Stadium: Oracle Park, San Francisco, CA
- Broadcast: NBC Sports Bay Area, MLB.tv
Key Storylines
- San Francisco is back in the mix in the NL Wild Card race. They are two games back of the Mets for the final National League playoff spot going into this contest.
- The Diamondbacks need some wins in a hurry. They have fallen to 4.5 games behind the Mets for that final Wild Card position and are running out of time to make up that ground.
- Both of these teams are right near the .500 mark in day games this season and will try to get a big win in this afternoon contest.
Pitching matchup
Eduardo Rodriguez enters with a 7-8 record, a 5.22 ERA, and a 1.60 WHIP across 131 innings. His recent form offers a more encouraging view. In his last two wins, he allowed one run across 13 innings, and his strikeout pace remains healthy enough to exploit a San Francisco lineup that has struggled against southpaws. The key for Rodriguez is fastball command to get ahead of the count and control at-bats.
Carson Seymour has flashed a live arm for the Giants. He has a 4.25 ERA and 1.35 WHIP across 29.2 big-league innings with 20 strikeouts. He’s allowed eight homers in that small sample, a red flag against an Arizona group that punishes mistakes from right-handers. Expect a shorter leash with San Francisco’s bullpen ready by the middle innings.
Recent team streaks
- The Arizona Diamondbacks have lost three straight games heading into this series finale.
- San Francisco has won two straight games heading into today.
Best Player Props
| Player | Prop |
|---|---|
| Eduardo Rodriguez | Under 5.5 Strikeouts |
| Carson Seymour | Over 4.5 Strikeouts |
| Corbin Carroll | Under 1.5 Total Bases |
| Willy Adames | 1+ Home Run |
Betting Trends & H2H
- The Giants hold a 5-4 lead in the season series against the Diamondbacks.
- San Francisco has won four straight games in the head-to-head between these teams.
Diamondbacks vs Giants Model Projection
Score Projection: Diamondbacks 4 – Giants 6
Win Probability: Diamondbacks 47%, Giants 53%
Final Thoughts
The San Francisco Giants are playing well of late and have given themselves a real chance in the NL Wild Card hunt. Rodriguez has been pitching better for the Diamondbacks lately but I’m not sold on that trend continuing on the road here. I’ll take San Francisco to win this game at home and to move even closer to the Mets before New York plays on Wednesday night.
