Arizona Diamondbacks vs San Diego Padres Pick – 7/10/2025

The Arizona Diamondbacks have won two of the first three games of their series against the San Diego Padres on the road. They will look to make it three out of four on Thursday night at Petco Park. To do that, the Diamondbacks will need to overcome the starting pitching advantage for the Padres in this matchup. Continue reading to find out more about that starting pitching matchup and everything else you need to know about this game, including our Diamondbacks vs Padres prediction.

Our Diamondbacks vs Padres Pick

• Pick: San Diego Padres moneyline
• Confidence: ★★★★☆
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Game Snapshot

• Matchup: Arizona Diamondbacks @ San Diego Padres
• Date & Time: Thursday, July 10, 2025, 9:40 PM ET
• Starting Pitchers: Eduardo Rodríguez (3-5, 5.78 ERA) vs Randy Vásquez (3-4, 3.79 ERA)
• Stadium: Petco Park, San Diego, CA
• Broadcast: Padres Television Network, Dbacks.TV, MLB Network

Key Storylines

• Pitching Form:
  • Eduardo Rodríguez is 3-5 with a 5.78 ERA. He is giving up over a hit per inning and has been a major disappointment for the D-Backs this year.
  • Randy Vásquez has posted a 3.79 ERA in his starts this season. Vasquez struggles with walks. But he has been good in just about every other area this year.
• Bullpen Usage:
  • Arizona’s bullpen ranks in the bottom five in ERA for the season.
  • The Padres are second in the league in bullpen ERA. They trail only the San Francisco Giants in that stat category.
• Recent Team Streaks:
  • The Diamondbacks are 3-2 in their last five games. They have won two of the first three games in this series.
  • The Padres have gone 2-3 in their last five games.

Best Player Props

Betting Trends & H2H

• Arizona has a 4-2 lead in the season series this year.
• The Diamondbacks are 30-29 in night games this season. The Padres are 28-30 in their night games.
• Arizona is a game over .500 on the road at 23-22. San Diego is 28-17 at home.

Diamondbacks vs Padres Model Projection

Score Projection: Arizona 4 – San Diego 5

Win Probability: Arizona 38%, San Diego 62%

Final Thoughts

The Padres have a starting pitching advantage going into this contest. Vasquez should be able to outperform the strugling Eduardo Rodriguez in this contest. Look for the Padres to get a win to even this series at 2-2 before these teams move onto other opponents over the weekend.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.