The Washington State Cougars and Ole Miss Rebels are set to face off on Saturday afternoon in Oxford. Ole Miss comes into this game at 5-0 and ranked fourth in the country. They will try to remain a top title contender with a win over one of two current Pac-12 teams. Here, I look at this game from all angles and you can find my Washington State vs Ole Miss prediction below.
Our Washington State vs Ole Miss Pick
- Pick: Ole Miss -31.5
- Confidence: 4/5
Game Snapshot
- Matchup: Washington State Cougars vs Ole Miss Rebels
- Date & Time: Saturday, October 11, 2025, 12:45 PM ET
- Venue: Vaught-Hemingway Stadium, Oxford, MS
- Broadcast: SEC Network
Washington State vs Ole Miss Odds
| Odds | Spread | Total |
|---|---|---|
| Washington State | +31.5 | Over 58.5 |
| Ole Miss | -31.5 | Under 58.5 |
Key Storylines
- Playoff Pressure: Ole Miss is ranked fourth in the country coming into this week. The key to the rest of the season for Ole Miss will be handling the pressure of high expectations. In this game, Ole Miss is a heavy favorite and will need to avoid being tripped up to remain in the top five in the rankings.
- Ole Miss’s Dominant Offense: Quarterback Trinidad Chambliss has been exceptional, leading the SEC in yards per attempt and completion rate. Ole Miss has scored over 40 points three times in five games and will try to do it again here.
- Washington State’s Defensive Struggles: The Cougars rank 116th in EPA/Play and 124th in success rate. They have had significant challenges in stopping opposing offenses.
- First-Ever Meeting: This game marks the inaugural matchup between these two programs, adding an element of unpredictability in this mid-season non-conference game.
Quarterback Play
Trinidad Chambliss has been a revelation for Ole Miss, throwing for over 1,000 yards with five touchdowns and just one interception. His ability to extend plays and make accurate throws under pressure has been a key factor in the Rebels’ success.
Washington State quarterback Zevi Eckhaus stepped in for Jaxon Potter last week, throwing for two touchdowns in a win over Colorado State. He will try to build on that performance this week against a much tougher opponent.
Betting Trends
- Ole Miss: The Rebels have won 15 straight games against non-conference opponents at Vaught-Hemingway Stadium.
- Washington State: Wazzu is 0-7 in its last seven road games against top-15 teams.
- Spread Trends: Ole Miss is 4-1 against the spread so far this season. Washington State is 2-3 against the spread going into this matchup.
Washington State vs Ole Miss Model Projection
Score Projection: Ole Miss 45 – Washington State 10
Win Probability: Ole Miss 95%, Washington State 5%
Final Thoughts
As much as I don’t like the idea of laying this many points in a college football game, I think Ole Miss is the right play against the spread here. The Rebels’ offense should prey on a Washington State defense that has really struggled when looking at the advanced metrics mentioned above. I expect the Rebels to get a convincing win and to move to 6-0 on the season in doing so.
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