The UTSA Roadrunners will go to Fort Collins to take on the Colorado State Rams in college football on Saturday night. Both of these teams are coming off wins against FCS opponents and will look for their first FBS wins of the year in this matchup. Here, I break down which team I think is more likely to get that FBS win as I bring you my UTSA vs Colorado State prediction.
Our UTSA vs Colorado State Pick
- Pick: Over 58.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: UTSA Roadrunners vs Colorado State Rams
- Date & Time: Saturday, September 20, 2025, 9:30 p.m. ET
- Venue: Canvas Stadium, Fort Collins, CO
- Broadcast: FS1
Key Storylines
- UTSA’s Offensive Surge: The Roadrunners are averaging 36.0 points per game, showcasing a potent offense led by quarterback Owen McCown and running back Robert Henry Jr. McCown has thrown for 583 yards and six touchdowns this season, while Henry has rushed for 480 yards and six touchdowns. Henry had a 74-yard touchdown against Incarnate Word in their last game and will look to make explosive plays again here.
- Colorado State’s Defensive Challenges: The Rams have allowed 27.5 points per game and 366.0 total yards per game. Their defense will face a significant test against UTSA’s high-powered offense.
- UTSA’s Road Struggles: The Roadrunners have struggled on the road, with an 0-5 record in their last five games played on a Saturday when playing on the road. Overcoming this trend will be a big test for them in this game.
Quarterback Play
- UTSA: Owen McCown has been efficient, completing 72 of 111 passes for 583 yards and six touchdowns. He hasn’t thrown any interceptions and will need to continue avoiding turnovers to help his team win here.
- Colorado State: Brayden Fowler-Nicolosi has completed 30 of 57 passes for 312 yards and one touchdown. He has also thrown two interceptions and has struggled without Tory Horton to throw to.
Betting Trends & H2H
- UTSA is 2-1 against the spread to start the 2025 college football season.
- Colorado State is 1-1 against the spread going into this contest.
- All three of UTSA’s games have gone over their totals.
- Colorado State is 1-1 on over/unders to begin this season.
- Colorado State leads the all-time series 2-0, with the last meeting occurring in 2016.
UTSA vs Colorado State Model Projection
- Score Projection: UTSA 36 – Colorado State 30
- Win Probability: UTSA 78%, Colorado State 22%
Final Thoughts
I think that we are in for a high-scoring game between UTSA and Colorado State here. Both offenses should have breakout performances now that they are facing FBS opponents that are not from power conferences. UTSA should win the game in the end, but my best bet for this non-conference matchup is for the game to go over the total.
