Clemson and Troy will meet in Week 2 of the college football season on Saturday afternoon. The Tigers lost at home to LSU in their season opener and will look to bounce back from that loss here. Troy is coming off a win over an FCS opponent and will look to shock the college football world. Before the action begins in Death Valley, continue reading to get my Troy vs Clemson prediction in the betting markets.
Our Troy vs Clemson Pick
- Pick: Under 51.5
- Confidence: 3/5
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Game Snapshot
- Matchup: Troy Trojans vs Clemson Tigers
- Date & Time: Saturday, September 6, 2025, 3:30 p.m. ET
- Venue: Memorial Stadium, Clemson, SC
- Broadcast: ACC Network
Troy vs Clemson Odds
| Spread | Total |
|---|---|
| Clemson –31.5 | 51.5 |
Key Storylines
- Clemson seeks rebound: Clemson will look to get their first win of the season after falling to LSU 17-10 in Week 1. Clemson’s offense sputtered in the second half against LSU. The team mustered just 10 points despite an early lead in a disappointing showing from quarterback Cade Klubnik.
- Troy’s fourth quarter firepower: Troy trailed FCS Nicholls State but erupted late to get a win. Troy scored 21 points in the final eight minutes to seal a 38-20 win. They will not be able to afford as slow a start this time around against a top 10 team.
- Rushing efficiency: Clemson struggled to move the ball on the ground against LSU while Troy moved it at will with their running game against Nicholls. We should see a role reversal in this game given the changes in level of competition for both teams.
Quarterback Play
- Cade Klubnik (Clemson): Klubnik completed 19 of 38 passes for 230 yards with one interception in Week 1. He should play better this week but beating up on Troy won’t answer many questions about Klubnik against quality competition.
- Goose Crowder (Troy): Crowder completed 14 of 24 attempts for 144 yards and 3 touchdowns. He also added a rushing touchdown and his ability to run could be a necessity against Clemson’s defense.
Betting Trends & H2H
- Clemson failed to cover the spread in their first game of the year.
- Troy also failed to cover the number in Week 1.
- Troy’s game went over its total and Clemson’s first game stayed under against LSU.
Troy vs Clemson Model Projection
- Score Projection: Clemson 42 – Troy 7
- Win Probability: Clemson 99%, Troy 1%
Final Thoughts
Clemson should dominate in Week 2 at home against a much smaller program than they faced in Week 1. The Tigers will move the ball a lot more efficiently than they did against LSU and the Clemson defense should stand tall once again. I’ll take the under as the best bet for this contest, as Clemson shouldn’t give up much of anything to the Troy offense and will be able to run the clock out late to help keep the total down.
