The Stanford Cardinal (1-2) will travel to Charlottesville to face the Virginia Cavaliers (2-1) on Saturday night. Both teams are coming off wins last week and will look for a second consecutive victory in their conference openers. Before kickoff in this ACC matchup, keep reading to get my Stanford vs Virginia best bet.
Our Stanford vs Virginia Pick
- Pick: Stanford +15.5
- Confidence: ★★★★☆
- Get Your Bonus Bets: Bet $5 and get $200 in bonus bets INSTANTLY using our DraftKings Sportsbook bonus. Click the Claim Bonus button below to start!
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
+ Parlay Profit Boosts All Season Long!
Gambling Problem? Call or TEXT 1-800-Gambler 21+ 
+ Parlay Profit Boosts All Season Long!
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Click To Claim
Claim Bonus
Promo Code: Click To Claim
Promo Code: Click To Claim
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
+ Parlay Profit Boosts All Season Long!
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Click To Claim
Claim Bonus
Promo Code: Click To Claim
Promo Code: Click To Claim
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Game Snapshot
- Matchup: Stanford Cardinal vs Virginia Cavaliers
- Date & Time: Saturday, September 20, 2025, 7:30 PM
- Venue: Scott Stadium, Charlottesville, VA
- Broadcast: ACC Network
Key Storylines
- Virginia’s Offensive Surge: The Cavaliers are coming off a dominant 55-16 victory over William & Mary. That was against an FCS opponent, though, and shouldn’t be seen as a sign of things to come in this matchup. Virginia will need to work harder to sustain their offense against a conference opponent here.
- Stanford’s Resilience: After an 0-2 start to the season, Stanford bounced back with a 30-20 win over Boston College. Running back Micah Ford was a standout, rushing for a career-high 157 yards and a touchdown. But Stanford’s defense will need to improve to keep pace with Virginia’s high-powered attack.
- Virginia’s Home Advantage: The Cavaliers have been strong at home. They enter this game with a 2-0 record at Scott Stadium this season. Their recent performances suggest they are building momentum and confidence as they enter ACC play.
Quarterback Play
- Chandler Morris (Virginia): Morris is off to a solid start for the Cavaliers. He has four touchdown passes and just one interception. He will try to avoid turning the ball over again in this game to help his team get another victory.
- Ben Gulbranson (Stanford): Stanford’s quarterback situation has been rough early in the season. Gulbranson has thrown one touchdown pass and three interceptions. He needs to be better if Stanford wants to hang around in this conference game.
Betting Trends & H2H
- Virginia’s Recent Form: The Cavaliers are 2-1 against the spread to open their season.
- Stanford’s Struggles: The Cardinal have a 1-2 record against the spread this season and will need to find an offensive spark to avoid another loss against the number.
- Over/Under Trends: Virginia has gone over the total in all three games this season, while Stanford has gone under the total in two of their three games.
Stanford vs Virginia Model Projection
- Score Projection: Virginia 28 – Stanford 17
- Win Probability: Virginia 78%, Stanford 22%
Final Thoughts
Virginia should be able to win this game at home against a Stanford team traveling across the country. But I think that the Cardinal will cover the spread as a huge underdog in this game. The Cardinal can play defense and we should see some regression from the Virginia offense after they destroyed an FCS team last week.
