Two SEC programs will collide on Saturday as South Carolina visits Missouri at Memorial Stadium in Columbia. South Carolina dropped its most recent game to Vanderbilt and will look to avoid an 0-2 start in conference play. Missouri is unbeaten through its three non-conference games and will look to continue their strong start to the season in their conference opener. Here, I break down this SEC showdown and give you my South Carolina vs Missouri prediction.
Our South Carolina vs Missouri Pick
- Pick: Missouri -13.5
- Confidence: 3/5
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Game Snapshot
- Matchup: South Carolina Gamecocks vs Missouri Tigers
- Date & Time: Saturday, September 20, 2025, 7:00 PM ET
- Venue: Memorial Stadium, Columbia, MO
- Broadcast: ESPN
Key Storylines
- South Carolina was crushed by Vanderbilt in their last game. The Gamecocks lost that contest 31-7 and fell to 0-1 in SEC play with that result. The Gamecocks are no longer ranked and are in danger of seeing their season get away from them in a hurry if they lose this contest.
- Missouri has won each of its first three games by double-digits. The Tigers have scored over 40 points in three straight games to begin the season. Missouri will look to impress in their SEC opener and avoid slowing down on offense here.
- This is the first road game of the season for South Carolina after going 2-1 at home to start the season. Missouri is playing at home for the fourth straight week.
Quarterback Play
LaNorris Sellers got hurt last week for the South Carolina Gamecocks. He was replaced by Luke Doty, who struggled in Sellers’ place. The question for South Carolina is whether or not Sellers can play and if he can be effective if he is able to go in this matchup.
Beau Pribula has ignited Missouri with his and mobility. He has thrown seven touchdown passes and just one interception to begin the year. This will be his biggest test of the season so far and it will be interesting to see how Pribula handles that.
Betting Trends & H2H
- South Carolina is 1-2 against the spread to start the season.
- Missouri is a perfect 3-0 against the spread to begin the year.
- The Tigers have gone over the total in each of their first three games of this year.
- South Carolina has stayed under the total in each of their first three games.
- Missouri holds a 9-6 lead in the all-time series against South Carolina.
South Carolina vs Missouri Model Projection
Score Projection: South Carolina 17 – Missouri 34
Win Probability: South Carolina 40%, Missouri 60%
Final Thoughts
South Carolina’s quarterback situation could get ugly if Sellers is not fully healthy for this game. That, combined with the Missouri offense being on fire early in the season, and we could see a lopsided game between these SEC teams. I recommend laying the points with Mizzou here, as they should move to 4-0 and turn some heads in their first SEC game of the season.
