The Louisiana Ragin’ Cajuns are set to face the Missouri Tigers on Saturday. The Tigers have worked their way into the top 25 after a strong start to the season. They will look to stay unbeaten against an opponent from the Sun Belt Conference. Here, I take a closer look at this non-conference matchup in college football and give you my Louisiana vs Missouri prediction.
Our Louisiana vs Missouri Pick
- Pick: Missouri -27.5
- Confidence: 5/5
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Game Snapshot
- Matchup: Louisiana Ragin’ Cajuns vs Missouri Tigers
- Date & Time: Saturday, September 13, 2025, at 1:00 PM EDT
- Venue: Faurot Field, Columbia, MO
- Broadcast: ESPN+
Key Storylines
Louisiana’s Offensive Struggles
The Ragin’ Cajuns have struggled offensively, ranking 133rd in passing yards per game with just 87. Their overall offensive output is 320 yards per game, placing them 105th in the nation. Quarterback Walker Howard has thrown for 88 yards and one interception. Running back Bill Davis has been the team’s most effective offensive weapon with 190 rushing yards and two touchdowns. But the Ragin’ Cajuns will need to find some offense through the air to compete in this contest.
Missouri’s Offensive Powerhouse
Missouri boasts one of the most potent offenses in the country. They have averaged 577.5 yards per game, including 337.5 passing yards per game and 240 rushing yards per game. Quarterback Beau Pribula has been efficient, completing 53 of 67 passes for 617 yards and five touchdowns. Running back Ahmad Hardy has contributed significantly, rushing for 212 yards and two touchdowns. Wide receiver Kevin Coleman Jr. leads the receiving corps with 16 receptions for 174 yards and one touchdown.
Betting Trends & H2H
- Missouri is 12–0 straight up in its last 12 home games.
- Missouri is 5–0 against the spread in its last five games as a favorite.
- Louisiana has been penalized 16 times for 195 yards this season, indicating potential discipline issues.
- Mizzou is 2-0 against the spread this season.
- Louisiana is 1-1 against the spread in 2025.
Louisiana vs Missouri Model Projection
- Score Projection: Missouri 45 – Louisiana 10
- Win Probability: Missouri 96%, Louisiana 4%
Final Thoughts
The lack of a passing game for Louisiana is a major concern for me going into this game. Missouri is explosive both through the air and on the ground. I expect the Tigers to win this game and cover the spread to improve to 3-0 on the season and solidify their position in the top 25.
