Duke Blue Devils vs Tulane Green Wave Prediction – 9/13/2025

The Tulane Green Wave will host the Duke Blue Devils in a non-conference college football matchup on Saturday night. Tulane enters this game as a slight favorite at home after a 2-0 start. They will face a familiar quarterback who transferred away from Tulane after last season. Here, I break down this matchup between teams from the ACC and AAC and give you my Duke vs Tulane prediction.

Our Duke vs Tulane Pick

• Pick: Tulane -1.5
• Confidence: 4/5
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4.8/5

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Game Snapshot

• Matchup: Duke Blue Devils vs Tulane Green Wave
• Date & Time: Saturday, September 13, 2025, 8:00 PM EDT
• Venue: Yulman Stadium, New Orleans, LA
• Broadcast: ESPN2

Duke vs Tulane Odds

Key Storylines

• Duke’s Quarterback Transition: Duke’s new quarterback is Darian Mensah. He is a transfer from Tulane and is adjusting to his new team. Any familiarity with Tulane’s defensive schemes could give the Mensah an edge in this matchup as he looks to prove he made the right choice to transfer.
• Tulane’s Strong Start: Tulane has started the season with a 2-0 record. Their first game was a convincing win over Northwestern. They followed that up with a win over South Alabama out of the Sun Belt. Their offense has been potent, averaging 255 rushing yards per game. They could certainly challenge Duke’s defense.
• Home-Field Advantage: Tulane has a strong home record playing at Yulman Stadium. Home-field advantage could play a significant role in this game, especially against an ACC team that is used to being at home in non-conference play.

Quarterback Play

• Duke: Darian Mensah has completed 50 of 68 passes for 723 yards, five touchdowns, and one interception. While his passing game has been effective, his familiarity with Tulane’s defense could be an advantage.
• Tulane: Quarterback Jake Retzlaff has thrown for 277 yards and two touchdowns. He has also rushed for 177 yards and two touchdowns. Retzlaff has shown off his dual-threat capability that could exploit Duke’s defensive schemes and made him so hard to stop at BYU.

Betting Trends & H2H

• Tulane is 1-1 against the spread to start this season.
• Duke is 0-2 against the spread early in the year.
• Duke is 2-0 to the oevr to begin their season.
• Tulane is 1-1 in the over/under market early on.

Duke vs Tulane Model Projection

• Score Projection: Tulane 31 – Duke 24
• Win Probability: Tulane 73%, Duke 27%

Final Thoughts

Tulane should be able to hold off Duke in this contest. The Green Wave know everything there is to know about Blue Devils quarterback Darian Mensah. They should slow down the Blue Devils’ passing game and force them into being a more one-dimensional rushing offense. I’ll take Tulane to win this game by a touchdown, as the Green Wave should be able to turn some heads before they face Ole Miss next week.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.