The Central Michigan Chippewas will face the Pitt Panthers on Saturday afternoon at Acrisure Stadium in Pittsburgh. Both teams enter the game with a 1-0 record but Pitt is a heavy favorite going into this matchup on their home field. Before this matchup between teams from the MAC and ACC, continue reading to get my analysis for this game, including my Central Michigan vs Pitt prediction in Week 2.
Our Central Michigan vs Pitt Pick
- Pick: Over 50.5
- Confidence: ★★★★☆
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Game Snapshot
- Matchup: Central Michigan Chippewas vs Pitt Panthers
- Date & Time: Saturday, September 6, 2025, 12:00 PM EDT
- Venue: Acrisure Stadium, Pittsburgh, PA
- Broadcast: ESPNU
Central Michigan vs Pitt Odds
| Central Michigan | Pittsburgh | |
|---|---|---|
| Spread | +21.5 | -21.5 |
| Moneyline | +1100 | -2500 |
| Total | 50.5 | |
Key Storylines
- Pittsburgh’s Offensive Efficiency: The Panthers’ offense put up 61 points in a blowout win over FCS opponent Duquesne in their season opener. This game should be more of a test for Eli Holstein and the Pitt offense. But the question will be how much resistance the Central Michigan defense can put forth in this contest.
- Central Michigan’s Defensive Strength: The Chippewas held San Jose State to just 14 points in their opening game. But they face a significant test here against Pittsburgh’s high-powered offense. The Chippewas also allowed 189 receiving yards to San Jose State receiver Danny Scudero and could be vulnerable against the pass here.
- Turnover Battle: Central Michigan went +3 in turnover margin last week and Pitt was a -1. Turnover regression for the Chippewas could make things even tougher on them this week.
Quarterback Play
- Pittsburgh: Eli Holstein has been a standout in his time at Pitt. He completed 65.2% of his passes for 215 yards and four touchdowns last week. His ability to make big plays will be key for the Panthers.
- Central Michigan: Central Michigan used a combination of Joe Labas and Angel Flores at quarterback. They had just over 100 passing yards in that game and that won’t be enough against a team like Pitt.
Betting Trends & H2H
- Both teams covered the spread in their season openers.
- Pitt went over the total in their first game after they scored 61 points in that contest.
- Central Michigan’s first game stayed under the total with 30 total points scored.
- This is the first all-time meeting between Central Michigan and Pitt in college football.
Central Michigan vs Pitt Model Projection
- Score Projection: Central Michigan 17 – Pittsburgh 38
- Win Probability: Central Michigan 12.9%, Pittsburgh 87.1%
Final Thoughts
Pitt’s explosive passing offense should have a field day against a Central Michigan team that got lit up by Danny Scudero and San Jose State last week. Pitt should win big here. Instead of laying the points with the Panthers, I will take the over in this game as Eli Holstein should lead the Panthers to another high-scoring game while the Chippewas put up enough points to get us to the total.
