The NFL season is up and running and Week 5 is another chance to put together winning NFL parlay picks this week. This week, our top NFL parlay pick is a pair of favorites that we expect to get wins in their respective matchups at home. Below, you will find my NFL parlay best bet for this week. Be sure to come back every week of the season for more parlay action.
NFL Week 5 Parlay Best Bet
NFL Parlay #1: Eagles over Broncos and Chargers over Commanders (+137)
First up this week, I will take the Philadelphia Eagles to win at home against the Denver Broncos. The Eagles are undefeated to start this season and their offense is firing on all cylinders. I expect that trend to continue this week against a Broncos team that is 0-2 on the road coming into this contest.
Then, we will close out this week’s parlay ticket by taking the Los Angeles Chargers to win at home against the Washington Commanders. The Commanders are expected to have Jayden Daniels back for this game. But he isn’t going to be at 100% from a health standpoint. On top of that, we should see the Chargers bounce back at home after a poor performance against the New York Giants last week.
2025 NFL Parlays Record: 2-2 (+0.31 units)
2024 NFL Parlays Record: 13-9 (+4.70 units)
When it comes to NFL parlay picks, expertise and reliability are essential. At ATS, our seasoned analysts leverage years of experience and cutting-edge statistical models to provide you with top-tier parlay picks for every NFL matchup. Whether you’re a seasoned bettor or exploring NFL parlays for the first time, our detailed breakdowns, including game spreads, money lines, totals, and player props, ensure you’re making informed decisions backed by data. With a track record of accurate predictions and insights, we’re your trusted partner for NFL betting success.
Every parlay pick we share comes with in-depth analysis and the best available odds from leading sportsbooks. From Sunday’s biggest games to prime-time showdowns on Monday and Thursday nights, we’ve got you covered. Explore our expertly curated NFL same-game and multi-game parlays, designed to maximize your potential payout while minimizing risk. With ATS, you’re not just betting, you’re betting smart.
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What Are NFL Parlay Bets?
NFL parlay bets are bets on pro football that combine multiple picks into one ticket. With parlay bets, every selection has to win in order for the parlay bet to be graded as a winner. These are, of course, harder to win than straight bets. But the odds are also set up so that bettors who win their parlays stand to make way more on the same risk amount as straight wagers.
The combinations of bets that can be put into parlays is virtually limitless, especially now that Same Game Parlays have been introduced at just about every major NFL sportsbook. These bets allow bettors to get creative with their NFL wagering, even if that creativity could cost them by reducing win probability.
Each week, you can find our recommended parlay bets from our NFL experts at this page. So bookmark this page, or just remember to come back to it on a regular basis, to get our parlays each week.
Types Of NFL Parlays
As we mentioned previously, bettors are more or less limited only by their imaginations when it comes to NFL parlay betting. There are a few main types of parlays that bettors will see from our team of NFL handicappers each week. Below, we break down each of those parlay types and the positives and negatives from playing them.
NFL Same Game Parlays
Same Game Parlays have become arguably the most popular form of NFL betting in the United States today. With NFL Same Game Parlays, bettors can make multiple picks from the same game, and combine them into one parlay ticket. While all of those legs still need to win in order for the parlay to cash, there is one advantage to playing Same Game Parlays that traditional parlays do not offer.
That major advantage is the fact that bettors can wager on selections that are correlated to one another. For example, if you select a team to win a game, it stands to reason that a player from that team would be worth betting to score a touchdown. While there is no guarantee that correlated legs of a parlay will all hit, betting this way can have a positive impact on a parlay’s win probability.
Multi-Game NFL Parlays
There are also NFL parlays that span multiple games, where bettors can wager on props or more traditional betting markets from multiple games in one parlay ticket. These types of parlays do not offer the same correlation possibilities as Same Game Parlays. However, that is not always a bad thing, as correlated parlays can go down in flames if your handicap of a game is not spot on.
With these parlays, bettors need to handicap multiple games well. But the rewards for doing so can be even more lucrative than betting on Same Game Parlays, as bettors can get great odds on moneyline parlays, especially when wagering on underdogs.
NFL Parlay Betting Strategies
From a strategic standpoint, there are ways to make NFL parlays work for you, even if they are harder to win at than placing straight bets. The following elements of strategy can help bettors place better parlays and maximize their chances of turning a profit when utilizing our NFL parlay picks.
Keep Parlay Bets Small
The most important thing bettors can do to improve their chance at winning with NFL parlays is to keep their parlay tickets small. While the allure of hitting a 15-leg NFL lottery ticket is certainly appealing, the chances of those huge tickets actually cashing is slim. Limiting parlay wagers to two or three legs will give bettors a better chance of actually winning money when placing their parlays.
You will notice that when we provide our NFL parlay bets this week and every week, that we keep our parlays to just a few legs at most. Doing that will prevent us from giving you advice that is exciting, but ultimately bad for your bankroll.
Handicap Each Leg Individually
A big question that bettors need to ask themselves when wagering on NFL parlays is whether or not they would wager on each leg individually. Bettors should thoroughly handicap each leg of any parlay they are thinking about betting. Doing this will help you to avoid making mistakes that will result in losing bets that could have been winners with just a little more homework.
Fortunately for you, our NFL experts live and breathe sports betting and NFL betting. That means doing the work of breaking down each leg of each parlay that we recommend, to make sure that you are delivered bets that you can not only feel confident placing, but that will actually win on a regular basis.
Are NFL Parlays Profitable?
The ultimate question when looking at our picks this week is whether or not parlay betting in the NFL is profitable. In general, parlay betting is not profitable, as parlays have the highest hold percentage of any type of bet in the world of sports gambling. But there are ways to maximize the profitability of NFL parlays.
By following the strategic recommendations above, bettors can improve their chances of turning a profit when making these types of bets. Be sure to come back to this page on a weekly basis to get our best parlay recommendations, which follow these strategic guidelines.
More NFL Best Bets
Here at ATS.io, we offer more than just NFL parlay picks. Be sure to click on the links below to get all of our other NFL predictions throughout the season, so you don’t miss a single pick.
- NFL Bets Of The Week
- Best NFL Teaser Bets
- Thursday Night Football Bets
- Sunday Night Football Predictions
- Free MNF Picks
- NFL Underdog Fantasy Picks
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ATS.io features affiliate links to licensed online casinos, sportsbooks, and gambling platforms. That means if you click on them and end up signing up or making a deposit, we might earn a commission at no extra cost to you. We only work with licensed and reputable online casinos, social casinos and sportsbooks. Our content whether it’s reviews, guides, or betting tips is written with the goal of being honest, helpful, and based on real experience. While we do earn through affiliate partnerships, it doesn’t affect our recommendations. If a site isn’t safe or doesn’t meet our standards, we won’t promote it. Simple as that. We also take responsible gambling seriously. We encourage all our readers to gamble safely, set limits, and know when to take a break. Have questions? Feel free to reach out. We’re always happy to chat.
