The Los Angeles Rams head into Week 14 as heavy favorites against the Arizona Cardinals in a game that looks like a one‑sided affair on paper. The Rams are riding high with a 9‑3 record and are tied at the top of the NFC West going into Sunday’s play. The Cardinals are 3‑9 and have struggled mightily all season, making this a key opportunity for Los Angeles to help their chances of winning the division. Here, I break down this matchup in the NFC West and make my Rams vs Cardinals prediction in Week 14.
Our Rams vs Cardinals Pick
- Pick: Cardinals +8.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Los Angeles Rams vs Arizona Cardinals
- Date & Time: Sunday, December 7, 2025, 4:25 PM ET
- Venue: State Farm Stadium, Glendale, AZ
- Broadcast: FOX
Key Storylines
- Rams looking to bounce back strong: Despite a recent loss to the Carolina Panthers that cost them the top spot in the NFC, the Rams remain one of the best teams in the league. With a 9‑3 record and wins in four of their last five games, they’re firmly in playoff contention. Their offense is led by an elite quarterback and a dynamic receiving corps and they will try to get back into the win column thanks to those weapons.
- Cardinals fighting for pride: Arizona is eliminated from postseason contention, but this game offers them a chance to salvage some respect and finish the season with dignity. Their offense under Jacoby Brissett has arguably been better than their offense with Kyler Murray at the helm this season. Arizona will try to play spoiler against their division rivals here, though that won’t be an easy task.
- Defensive mismatch looming: The Rams’ defense remains among the more sound units in the league. Arizona’s offensive line has struggled to protect Brissett, and given the Cardinals’ issues in pass protection, Los Angeles could exploit this by applying pressure on Brissett and generating turnovers.
Quarterback Play
For the Rams, Matthew Stafford leads one of the NFL’s most efficient offenses. He enters the game with 3,073 passing yards, 32 touchdowns, and just 4 interceptions. His connection with his receiving targets like Puka Nacua and Davante Adams has been impressive all year long. On the other side, Jacoby Brissett has kept the Cardinals afloat as well as possible, but his offense lacks the explosive weapons and pass protection to consistently challenge elite defenses.
Betting Trends
- The Rams are 8-4 against the spread going into this contest.
- Arizona is 6-6 against the spread so far this year.
- The Cardinals have gone over the total in 7 of their first 12 games.
- The under has cashed 7 times in Arizona’s first 12 outings.
Rams vs Cardinals Model Projection
Score Projection: Rams 27 – Cardinals 21
Win Probability: Rams 78%, Cardinals 22%
Final Thoughts
The Rams should be able to come away with an important in this game to get to 10 wins on the year and stay on top of the NFC West. But I’m taking the points with Arizona here, as Brissett should be able to lead just enough scoring drives to keep this game within a possession at home.
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