Updated September 3, 2026
The Tulane Green Wave and Duke Blue Devils open their 2026 college football seasons with an intriguing nonconference matchup on Saturday, September 5, at Brooks Field at Wallace Wade Stadium in Durham. Duke enters the season as the defending ACC champion, while Tulane is coming off an 11-win campaign, an American Conference championship, and the first College Football Playoff appearance in program history. Both programs have undergone notable changes since then, making their Week 1 rematch particularly interesting to project.
Tulane vs Duke Prediction: Tulane +7.5
Duke deserves to be favored at home, but getting more than a touchdown with Tulane is appealing. The Green Wave have established themselves as one of the strongest Group of Six programs in recent seasons, and despite significant personnel turnover, there is enough talent remaining for Tulane to keep this competitive. Duke also has important questions to answer after losing several major contributors from its ACC championship roster.
Prediction-market pricing reflects greater confidence in the Blue Devils winning outright. Polymarket currently prices Duke at approximately 73% to win, compared to roughly 27% for Tulane. That is a substantial gap, but the point spread creates a different decision. Tulane does not necessarily need to pull off the upset to deliver value at +7.5, and a one-score loss would be enough for the Green Wave to cover.
There should be no shortage of motivation for Duke after what happened when these teams met last September. Tulane jumped out to a 24-3 advantage in New Orleans and eventually held on for a 34-27 victory.
Duke produced 452 total yards and rallied late, but the early deficit proved too much to overcome. The rematch shifts to Durham, where the Blue Devils will have an opportunity to return the favor in their season opener.
The Tulane team taking the field Saturday will look considerably different from the one that won the American Conference and reached the College Football Playoff last season.
Jon Sumrall departed to become Florida's head coach, with Will Hall promoted to replace him. Hall already has extensive familiarity with the program after previously serving as Tulane's offensive coordinator and returning to the staff in 2025.
Quarterback Jake Retzlaff is also gone after accounting for four rushing touchdowns against Duke last season. Houston transfer Zeon Chriss-Gremillion is expected to take over an offense that will rely on several new contributors. Tulane's biggest uncertainty could be in the trenches, where substantial turnover has created questions on both sides of the ball.
Duke has a significant quarterback change of its own. Darian Mensah transferred to Miami after throwing for 3,973 yards during Duke's ACC championship season.
Manny Diaz has named San Jose State transfer Walker Eget the new starter. Eget brings considerable experience to Durham after throwing for 3,051 yards with 17 touchdowns in 2025. Having an experienced transfer rather than an untested quarterback should make the transition easier, particularly with 1,100-yard rusher Nate Sheppard returning to the backfield.
Tulane's rebuilt offensive line against Duke's defensive front could determine whether the Green Wave stay inside the number. Chriss-Gremillion is dangerous with his legs, but Duke will want to put him in obvious passing situations and force the new Tulane offense to execute consistently.
On the other side, watch Eget against an experienced Tulane secondary led by safety Jack Tchienchou. Duke should have opportunities offensively, but turnovers and explosive plays could allow Tulane to shorten the game. If the Green Wave can avoid falling behind early as Duke did in last year's meeting, Tulane +7.5 has a strong chance to remain competitive deep into the fourth quarter.
