Los Angeles Lakers vs San Antonio Spurs Preview & Prediction – 1/7/2026

The Los Angeles Lakers will travel to San Antonio to take on the Spurs on Wednesday night in a big Western Conference matchup in the NBA. Both teams enter this contest on the second legs of back-to-backs and will have to perform on a quick turnaround in this contest. Before the action begins in San Antonio, keep reading to get my thoughts on the game, including my Lakers vs Spurs prediction.

Our Lakers vs Spurs Pick

Game Snapshot

• Matchup: Los Angeles Lakers @ San Antonio Spurs
• Date & Time: Wednesday, January 7, 2026, 9:30 PM ET
• Venue: Frost Bank Center, San Antonio, Texas
• Broadcast: ESPN

Key Storylines

The Lakers are riding a three‑game win streak, most recently defeating the New Orleans Pelicans on the road on Tuesday night. Their offense is led by Luka Dončić, who is averaging over 33 points, nearly 9 assists, and nearly 8 rebounds per game. However, Los Angeles has some notable absences that could affect their chances in this game. Austin Reaves and Rui Hachimura are out, while Gabe Vincent is questionable. We could also see LeBron James’ workload diminished on the second game of a back-to-back. These injuries could hamper their ability to keep pace with San Antonio’s pace and space scoring. The Lakers are averaging about 117 points per game but their defensive rating suggests they can be exploited by explosive offenses.

The Spurs are coming off a road loss to the Memphis Grizzlies last night, despite a strong performance from Victor Wembanyama, who scored 30 points off the bench in limited minutes. San Antonio has played high‑tempo basketball of late, using their ability to push pace and spread the floor to create good shots consistently. De’Aaron Fox and Stephon Castle provide dynamic guard play, which pairs so well with what Wemby can do. Wembanyama’s minutes restriction makes his status for Wednesday an important thing to watch. It is entirely possible that the Spurs rest him for this game, while Devin Vassell is questionable after sitting on Tuesday. San Antonio’s 12‑5 home record is impressive and they will try to improve on it here.

Head‑to‑Head & Betting Trends

• These teams are 1-1 against each other so far this season, with both of those games being played in Los Angeles.
• The Lakers are 20-14 against the spread so far this season.
• San Antonio is 18-17-2 against the spread going into this game.
• The over is 21-13 in Lakers games this year.
• The under is 20-17 in games involving the Spurs this season.

Best Player Props to Watch

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.