Seattle Seahawks vs Arizona Cardinals Prediction - September 20, 2026

Matchup Overview

Arizona opened the season with a strong offensive showing, scoring 26 points and producing 393 total yards in its first game, but it also allowed 268 yards and 14 points while finishing with a positive turnover margin. Seattle also started 1-0, but its profile is more balanced: the offense produced 13 points and 285 yards, while the defense held the opponent to 10 points and 277 yards. The clearest separator is efficiency on both sides of the ball, where Seattle’s yards-per-play numbers are stronger on offense and defense, giving it a steadier base if this game settles into a lower-scoring, possession-driven script.

Betting Trends

• ●Arizona Cardinals are 1-0 against the spread and 0-1 to the over this season.
• ●Seattle Seahawks are 0-0-1 against the spread and 0-1 to the over this season.

Prediction Summary

Seattle has the better blend of defensive efficiency, turnover profile, and overall stability, so the Seahawks are the side I favor in this matchup. Arizona can score enough to keep it close, but the Cardinals’ weaker defensive numbers make it harder to trust them to finish the job. My projected final score is Seattle 24, Arizona 20, which supports Seattle on the moneyline and points to a moderately scored game.