Updated November 10, 2025
The early non-conference clash between the Iowa State Cyclones (2-0) and the Mississippi State Bulldogs (1-0) on Monday night is set to be the game of the night in college basketball. Iowa State enters the game as a favorite, but this game is being played at a neutral site and the Cyclones won't be able to rely on Hilton Magic here. Before tip-off from Sioux Falls, continue reading to get my Mississippi State vs Iowa State prediction.
Pick: Iowa State −5.5
Confidence: ★★★★☆
Matchup: | Mississippi State Bulldogs @ Iowa State Cyclones |
Date & Time: | Monday, November 10, 2025, 8:00 PM ET |
Venue: | Sanford Pentagon, Sioux Falls, South Dakota |
Broadcast: | ESPNU |
Score Projection: Iowa State 80 – Mississippi State 68
Win Probability: Iowa State 70%, Mississippi State 30%
I'm very high on this Iowa State team this season. Their veteran experience and execution will do them a world of good early in the season and late in the season. I think they get a win and cover the spread in this neutral site matchup against a Mississippi State team that doesn't have the same scoring depth that the Cyclones do.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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