The Buffalo Bills and New England Patriots their rivalry in a huge game on Sunday with the AFC East title on the line. The Patriots (11-2) arrive in Foxborough riding a 10-game winning streak and control the division with a victory, while the Bills (9-4) are fighting to keep their own hopes alive with a win in this Week 15 showdown. Before this game kicks off with so much on the line, keep reading to get my Bills vs Patriots prediction.
Our Bills vs Patriots Pick
Game Snapshot
- Matchup: Buffalo Bills vs New England Patriots
- Date & Time: Sunday, December 14, 2025, 1:00 PM
- Venue: Gillette Stadium, Foxborough, Massachusetts
- Broadcast: CBS
Key Storylines
This Week 15 matchup carries significant divisional and playoff implications as the Bills and Patriots fight for position in the AFC East. The Patriots have surged to an 11-2 mark and could clinch the division with a win, while Buffalo remains within reach at 9-4 and could pull to within a game with a win here. The last meeting between these teams was decided by three points in favor of New England, but the Bills are favored as they try to get revenge this week.
On the Bills’ side, multiple players are listed as questionable, and star corner Christian Benford’s status has been uncertain due to a injury. That could lead to some added pressure on the Buffalo secondary. For the Patriots, linebacker Robert Spillane is questionable, but New England overall comes into the game relatively healthy and confident after a long winning streak.
Quarterback Play
The duel at quarterback features two of the league’s most dynamic signal-callers. Josh Allen leads the Bills with prolific passing and rushing numbers, and his dual-threat ability poses constant problems for opposing defenses. His ability to run and throw makes him especially dangerous in red zone and third down situations.
New England’s Drake Maye has continued his ascent with efficient passing statistics and a growing ability to extend plays with his legs. Maye has over 3,400 passing yards for the season and he continues to get love in the race for the MVP award because of his individual contributions and the performance of his team.
Betting Trends & H2H
- This pairing has already produced a thriller earlier this season in Buffalo, with New England escaping with a 23-20 victory.
- The Patriots are on a 10-game winning streak and are 8-4-1 against the spread this season.
- The Bills are 6-7 against the spread this season and have struggled to consistently cover as road favorites.
- The Patriots have gone over the total in 7 of their 13 games.
- Buffalo has stayed under the total in 7 of their 13 outings.
Bills vs Patriots Model Projection
Final Thoughts
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