USC Trojans vs Oregon Ducks Prediction - 11/22/2025
Updated November 21, 2025
Updated November 21, 2025
The USC Trojans head into Autzen Stadium on Saturday to take on the Oregon Ducks in a marquee Big Ten matchup. This game is more or less an elimination game in the College Football playoff race, as a loss this late in the season would make it hard for the team that drops this one to move back up to get an at-large spot. Here, I break down this big game in the Big Ten and give you my USC vs Oregon prediction for this contest.
Pick: USC +10.5
Confidence: 3/5
USC: Jayden Maiava has thrown for 2,868 yards with 18 touchdowns and 6 interceptions this season. He completes nearly 67% of his passes and he also brings some mobility when needed. Maiava is the latest quarterback to have success under Lincoln Riley and he will try to lead his team to an upset win in this contest.
Oregon: Dante Moore has put together a very efficient season for Oregon. He has thrown for 2,190 yards with 21 touchdowns and 5 interceptions. He is completing more than 72% of his passes going into this matchup. In Oregon’s last game, Moore completed 27 of 30 throws for 306 yards and 2 scores.
Score Projection: Oregon 35 – USC 28
Win Probability: Oregon 72%, USC 28%
Oregon should be able to win this game at home to keep their College Football Playoff hopes alive while ending the hopes of the Trojans. But I am taking the points with USC in this matchup. The Trojans have an explosive enough offense to hang with Oregon for the most part and Maiava should be able to move the ball effectively enough through the air to keep this contest within single digits.
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