Houston vs Oklahoma State Pick & Prediction - 10/11/2025
Updated October 10, 2025
Updated October 10, 2025
Houston and Oklahoma State will play on Saturday afternoon in a Big 12 matchup from Stillwater. The Cougars are off to a 4-1 start this year and will try to continue their winning ways against a struggling Oklahoma State squad. Here, I break down this big game in the Big 12 and give you my Houston vs Oklahoma State prediction for this weekend.
Odds | Line |
|---|---|
Spread | Houston –14.5 |
Moneyline | Houston –750, Oklahoma State +475 |
Total | 48.5 |
Weigman has completed 70 of 118 passes for 910 yards with six touchdowns and two interceptions this season for Houston. Flores had completed just 77 of 140 passes this season before his injury, with no touchdowns and three interceptions. His replacement options are unproven and will be thrown right into the fire here.
Score Projection: Houston 35 – Oklahoma State 17
Win Probability: Houston 85%, Oklahoma State 15%
Houston enters this game as the far more reliable and complete team. With Weigman back, the Cougars can execute their offense effectively, while Oklahoma State’s offense is plagued by instability and inexperience at quarterback. Houston’s defense should control the line of scrimmage and force turnovers. I expect Houston to win by a comfortable margin and cover the two-touchdown spread, as the Cougars should improve to 5-1 overall and 2-1 in the Big 12.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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