Arizona vs Iowa State Pick & Prediction - 9/27/2025
Updated September 26, 2025
Updated September 26, 2025
Arizona and Iowa State will meet in Big 12 play on Saturday night. This showdown is one of the more intriguing early Big 12 clashes this season. Arizona arrives flying high at 3-0 and with one of the stingiest defenses in the country. Iowa State rolls in at 4-0 as the conference favorite. Only one team can come out of this game with their undefeated record in tact. Continue reading to find out who I think that will be as I make my Arizona vs Iowa State prediction.
Odds | Line |
|---|---|
Spread | Iowa State –4.5 |
Moneyline | Iowa State –195, Arizona +165 |
Total (Over/Under) | 48.5 |
Noah Fifita of Arizona has been remarkably clean so far. He has 712 passing yards, six touchdowns, and no interceptions. He has also added value as a runner, with three rushing touchdowns. His decision-making has been a strength for the Wildcats. Rocco Becht is a veteran presence for the Cyclones. He has 860 yards, seven touchdowns, and one interception. Becht may push the ball downfield against Arizona’s secondary. But Arizona’s defense might make life uncomfortable for him.
Score Projection: Iowa State 27 – Arizona 17
Win Probability: Iowa State 68%, Arizona 32%
It will be interesting to see how Arizona handles being on the road for the first time this season. The Wildcats are 3-0 but have yet to leave Tucson. I think they will struggle to adjust to life on the road this weekend in Ames. I'll take Iowa State to win and cover the spread in this battle of undefeated Big 12 squads.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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