There are 16 games on the MLB schedule on September 16, 2025. That means plenty of avenues we can take to put together winning MLB parlay picks. Our parlay of the day for Tuesday’s MLB action is a two-leg moneyline parlay featuring a couple of teams that we expect to get wins in their respective matchups. You can find today’s top MLB parlay prediction below.
MLB Parlay Pick Of The Day
Two-Leg Moneyline Parlay: Risk $100 to Win $145 (+145)
Pick 1: Braves ML (-192) over Nationals (Game 2)
Pick 2: Red Sox ML (-163) over Athletics
Reasoning: Up first, we will take the Atlanta Braves to get a win in Game 2 of their doubleheader against the Washington Nationals. The Braves have Chris Sale on the mound in the second game of their twin bill against the Nats. That should give Atlanta all the advantage they need to get the victory in this contest from Nationals Park.
Then, we will take the Boston Red Sox to close out our parlay ticket with a win at home against the Athletics. Boston has an exciting young pitcher on the mound in this game in Connelly Early. Early struck out 11 Athletics in his debut on the bump for Boston last week. He should pitch well again here to help the Sox get a win at home.
Today’s MLB Game Previews
- MLB
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
Gambling Problem? Call or TEXT 1-800-Gambler 21+ 
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Promo Code: Click To Claim
Bet $5, Get $200 in Bonus Bets Instantly + Over $200 Off NFL Sunday Ticket
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Promo Code: Click To Claim
Gambling Problem? Call or TEXT 1-800-Gambler 21+
Parlay betting in Major League Baseball is a way to potentially amplify your winnings by combining multiple wagers into a single bet. With years of experience analyzing MLB games and trends, we’ve mastered the art of identifying value in parlay bets to give you the best possible edge. Our team of seasoned baseball experts diligently researches every matchup, considering factors like player form, pitching matchups, and team dynamics to craft daily MLB parlay picks you can trust.
Whether you’re new to parlay betting or a seasoned bettor looking to refine your strategy, our insights are designed to help you make informed decisions. Along with expert picks, we provide the reasoning behind each leg we include in those selections. Explore our comprehensive guide below and find out which MLB parlays we like every day throughout the baseball season.
What Are MLB Parlay Picks
Our free MLB parlay picks are bets that consist of two or more MLB predictions, combined into one single ticket. Each of those MLB picks needs to win in order for the parlay ticket to be graded as a winner. The appeal of these bets is that combining multiple predictions into one bet increases the potential payout of the wager, making it possible to turn a small wager into a large payout if every pick wins.
How to Win MLB Parlay Bets
MLB parlays, and parlay bets in general, carry more risk than single bets. With these wagers featuring multiple bets in one ticket, the probability of picking everything correctly is lower. However, our MLB parlay strategies can help maximize the chances of overcoming the parlay odds with each bet you place using our recommendations.
Stick to Small MLB Parlays
The smartest thing that bettors can do when placing an MLB parlay is to stick to small parlays of two or three picks maximum. While the potential payouts for these parlays is smaller than a 10-leg lottery ticket, the chances of winning are also higher. Baseball picks can be volatile enough without adding too many legs to the mix.
Look For Value
As is the case with any type of bet, bettors should look for value when betting on parlays in baseball. Shopping around at their favorite sportsbooks for the best odds on each leg can deliver bettors significantly better parlay odds when locking in their selections. While this may not seem important in a one-parlay sample size, it can make a huge difference in the long run.
Bettors can also find value by analyzing the games that are on the MLB schedule to find betting angles that are profitable on any given game. For example, if the Houston Astros are dealing with injuries going into a game against the New York Yankees, the Yankees could have an edge that they may not have otherwise. That could give bettors a better chance to win than the parlay odds they lock in would suggest.
Types Of MLB Parlays
There are multiple types of MLB parlay that bettors can wager on, which our team of MLB betting experts consistently use when betting on baseball. Here, we will break down the different types of MLB parlays out there, and what you can expect when you come back on a regular basis for our parlay picks.
MLB Same Game Parlays
SGPs are the most popular type of parlay in baseball and any other sport right now. With these parlays, bettors are able to select multiple parlay legs from a single game. All of those legs still need to win in order for the parlay to cash, but there is an advantage to using these that does not exist when betting on a multi-game parlay.
That advantage would be the ability to put together multiple picks that are correlated to one another into a parlay ticket. For example, let’s say that there is an American League game going on between the Cleveland Guardians and Seattle Mariners. If a bettor thinks that the Guardians are going to win a low-scoring game thanks to Cleveland’s style of play, they can combine the Guardians and the under together. Backing those two related results can increase the chances of winning an SGP.
The great thing about the boom in popularity surrounding SGPs is that they are available all season long in baseball. Every game from the most insignificant regular season matchup to MLB postseason games featuring elite teams such as the New York Yankees and Houston Astros feature the ability to bet on SGPs, to the benefit of new and experienced bettors.
Parlays on Multiple Games
There is also the ability to bet on parlays that feature picks from different contests around Major League Baseball. For example, a bettor can wager on the moneyline of a game between the New York Yankees and Houston Astros, and combine it with the outcome of a game between the Seattle Mariners and Cleveland Guardians.
The one drawback to this approach is that the results of multiple contests are not related to one another in any way. While a Same Game Parlay allows bettors to combine outcomes that are correlated, the result of each individual baseball game is independent from one another. That can reduce the chances of hitting these types of bets, even if they are a popular type of wager.
More than MLB Parlay Picks
Beyond the MLB parlays that we have listed here, there are several other types of MLB picks that we make all season long. Just click on the links below to be taken to the MLB page you wish to visit, to get recommendations on individual MLB games, futures, and more.
Best NRFI Bets Today: No Run First Inning Picks For September 16, 2025
Athletics vs Boston Red Sox Pick – 9/16/2025
