Tennessee Titans vs Arizona Cardinals Prediction - 10/5/2025
Updated September 29, 2025
Updated September 29, 2025
The Tennessee Titans will visit the Arizona Cardinals in Week 5 of the NFL season on Sunday. Both teams come into this game on losing streaks. The Titans are winless on the season and will look to play better football this week. Arizona has dropped two games in a row and will try to start digging out of last place in the NFC West. Before kickoff from Glendale, continue reading to get my Cardinals vs Titans prediction for this week's game.
Line | Moneyline | Total |
|---|---|---|
Cardinals –9.5 | Cardinals –550 / Titans +380 | Over/Under 41.5 |
Cam Ward has had a brutal start to his professional career. He's completing just over half his passes with two touchdowns and two interceptions. He’s yet to display command of the Titans' offense and he has to show some improvement soon if the Titans want to be a respectable football team anytime soon.
Kyler Murray has been serviceable for the Cardinals thus far. He’s thrown six touchdowns and three interceptions to this point. His mobility gives Arizona an added dimension on offense. And he got an encouraging showing out of wide receiver Marvin Harrison Jr. after a tough start to last week's game against Seattle.
Score Projection: Cardinals 27 – Titans 13
Win Probability: Cardinals 86%, Titans 14%
Cam Ward said it best when he said that the Titans were playing like, and I quote, "ass" to begin the season. The Titans are averaging 12.75 points per game through four games and their struggles on offense should continue against a desperate Cardinals team this week. I will lay the points with Arizona, who should improve to 3-2 and put an end to their two-game losing streak.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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