Tampa Bay Buccaneers vs Seattle Seahawks Prediction - 10/5/2025
Updated September 29, 2025
Updated September 29, 2025
The Tampa Bay Buccaneers and Seattle Seahawks will meet in Week 5 of the NFL season. Tampa is looking to rebound from a tough loss at home this week, while the Seahawks aim to build on a dramatic last-second victory. Seattle enters as a favorite at home as they look for their fourth win in a row. Before this matchup between NFC teams with 3-1 records, you can find my Buccaneers vs Seahawks prediction below.
Spread | Moneyline | Total |
|---|---|---|
Seahawks −3.5 | Seahawks −185 / Bucs +155 | 44.5 points |
Baker Mayfield has shown poise in close games so far this season. In Week 4, Mayfield attempted 40 passes for 289 yards, two touchdowns, and one interception. Seattle’s defense will aim to bring heat from all angles at Mayfield and the Bucs' signal caller will try to avoid being impacted by a good defense on the road here.
Sam Darnold has played well thus far in his first season in Seattle. Darnold has completed 70% of his passes so far this year, with five touchdown passes and two interceptions. He is doing exactly what Seattle needs him to do to win games by avoiding turnovers and simply managing games effectively.
Score Projection: Tampa Bay 20 – Seattle 24
Win Probability: Tampa Bay 38%, Seattle 62%
Seattle has a rest advantage and home-field advantage going into this game. The Bucs tend to play up or down to their level of competition and certainly won't make this an easy game for the Seahawks. But I do recommend laying the points with Seattle, as they should get a fourth straight win at the expense of the road-weary Bucs.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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