MLB season is here and that means chances to wager on MLB player props. There are 15 games on the MLB schedule for September 17, 2025. Among those games is a matchup between the Chicago Cubs and Pittsburgh Pirates, which is the focus of our MLB prop action for the day. Below, we make our top pick in the prop markets for today’s action as we look to put together another big year in the prop betting markets on the diamond.
MLB Prop Bets for September 17, 2025
| Game | Best Bet |
|---|---|
| Cubs vs Pirates | Matthew Boyd to record the win (+158) |
Chicago Cubs vs Pittsburgh Pirates – 12:35 PM ET
Our top pick among MLB player props on Wednesday is from the game between the Chicago Cubs and Pittsburgh Pirates. In that game, I’ll take Cubs starter Matthew Boyd to record the win. Boyd has been excellent for the Cubbies this year, ranking in the top 15 in MLB in ERA on the season. I expect him to continue pitching well in this game against a Pirates team that has failed to beat Chicago with Paul Skenes on the mound already this week.
Best Bet: Matthew Boyd to record the win (+158) vs Pirates
Prop Notes
- Boyd already has a win over the Pirates this season.
- Boyd gave up one run in six innings of work against Pittsburgh the last time he faced them.
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MLB prop bets offer a unique and exciting way to engage with baseball, focusing on individual player performance and specific in-game events rather than overall team outcomes. From predicting a pitcher’s strikeouts to wagering on a batter’s total bases, these bets cater to both casual fans and seasoned pros looking for creative ways to get in on the action. With our trusted expertise and data-driven approach, you’ll gain the edge you need to turn today’s MLB slate into a profitable betting experience.
Looking to elevate your MLB prop betting? You’ve come to the right place, as our team of seasoned MLB analysts breaks down the most promising prop betting opportunities for today’s matchups here throughout the MLB season. Whether you’re eyeing strikeouts, home runs, total bases, or another market, we’ve done the heavy lifting by analyzing player tendencies, team matchups, and game-day conditions to deliver expert insights. With years of experience in MLB betting and a proven track record of success, we’re here to help you make informed decisions and maximize your betting ROI.
How We Pick Our MLB Player Props
Each day throughout the 2025 MLB season, our MLB handicapping experts look through the prop markets to find player props that we recommend for you to bet on. But how do we decide on which props to play and which props to pass on? Below you will find information on the tools we use and the strategies we employ to come to those decisions.
Statistical Analysis
The most important thing when deciding on MLB prop bets or any other bet to make is to perform a thorough statistical analysis. This allows us to determine where there is value relative to the betting lines that sportsbooks have made available. We perform this analysis through our projection systems, which our handicapping experts use to determine where it may be favorable to place certain wagers.
While look at basic stats like batting average and ERA are good first steps, what sets us apart from your average sports bettor is that our statistical models go much deeper than that. Looking at all of the numbers that could go into a given matchup to come up with projections for each player’s statistical outputs, we leave no stone unturned in picking our MLB props each day.
Matchup Analysis
Along with running the numbers, we look closely at the matchups that each player is up against going into each game. This means evaluating a number of factors, from which pitchers are going up against which hitters, to breaking down lineups to determine which hitters are more likely to see pitches to hit and which hitters could be pitched around. We also look closely at which pitchers may be on shorter leashes than others, helping us to get a full picture of how each hurler will perform on the hill.
Ballpark Analysis
Baseball betting is unique because every ballpark is unique. Every park has different dimensions, weather patterns, and other quirks that can impact pitchers and hitters in different ways. Failure to take those differences into account can do serious damage to a bettor’s chances of winning when betting on MLB props.
Fortunately, we regularly look at the ballpark factors that will come into play for the players in each MLB matchup. This allows bettors to trust our analysis, as it is anything but cookie-cutter commentary.
Types Of MLB Player Props We Look At
There are so many different prop markets to bet on in Major League Baseball, as pitchers and hitters both have their own prop categories to choose from. Below is a little more information on the types of prop bets that we look at each day and you could see in our best MLB prop bets today.
Pitching Props
With pitchers, there are a number of statistical categories that have their own prop markets. Bettors can wager on everything from how many strikeouts a pitcher will rack up in a game to whether or not that pitcher will be credited with the win at the end of that game. Below is a list of the different MLB prop markets that are typically available for pitchers.
- Strikeouts
- Outs Recorded
- To Record a Win
- Hits Allowed
- Earned Runs Allowed
- Walks Allowed
Hitting Props
Hitters have an even longer list of prop markets that bettors can choose from. There are props such as home runs, hits, and RBI up for grabs. But that is just a small sample of the prop options for hitters, with a more comprehensive list of those props below.
- Home Runs
- Hits
- Total Bases
- RBI
- Runs Scored
- Hits + Runs + RBI
- Stolen Bases
- Strikeouts
- Singles
- Doubles
- Triples
- Walks
More Than Just MLB Player Props
Baseball bettors can find more than just MLB prop bets here at ATS. We break down the action on the diamond from all angles, including single-game bets, parlays, and futures wagers. Bettors can click on the links below to get more picks, previews, and analysis from our team of experts.
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