Chicago Cubs vs Arizona Diamondbacks Pick – 3/27/2025

As the 2025 MLB season commences, fans are eager to witness the Chicago Cubs take on the Arizona Diamondbacks at Chase Field in Phoenix on Thursday, March 27, 2025. Both teams have undergone significant changes during the offseason, setting the stage for an intriguing opener that promises excitement for bettors and enthusiasts alike.

Chicago Cubs vs Arizona Diamondbacks Game Preview

The Cubs enter this season with a revamped roster, featuring 17 players who joined the organization after Opening Day 2024. This substantial turnover highlights the team's commitment to building a competitive squad.

However, the Cubs face challenges as they begin the season. Second baseman Nico Hoerner is recovering from offseason surgery on a right flexor tendon tear and did not travel with the team for their initial games. While he participated in a recent Cactus League game, his availability for Opening Day remains uncertain.

On the mound, left-hander Justin Steele is slated to start for Chicago. Steele's performance will be under scrutiny as he aims to lead the Cubs effectively in this season opener.

In contrast, the Diamondbacks are determined to start strong after narrowly missing the playoffs in 2024. They will rely on right-hander Zac Gallen to set the tone for their season. Gallen's consistency and ability to handle the pressure of an Opening Day start will be crucial for Arizona's aspirations.

Betting Insights

Betting markets have identified the Diamondbacks as the favorites for this matchup. As of March 27, 2025, the odds are as follows:

• Moneyline: Diamondbacks -130, Cubs +110
• Spread: Diamondbacks -1.5 (+155), Cubs +1.5 (-190)
• Total Over/Under: 8.5 runs

Historical betting trends provide additional context. The underdogs have won seven of the last eight games between the Cubs and Diamondbacks at Chase Field. Additionally, the Diamondbacks have lost six of their last nine games as home favorites, suggesting inconsistency in meeting expectations when favored.

Chicago Cubs vs Arizona Diamondbacks Prediction

Considering the offseason adjustments, current player statuses, and betting insights, the Diamondbacks appear to have the edge in this opener. Their status as home favorites, combined with the Cubs' uncertainties surrounding key players like Hoerner and the challenges faced by Steele, points toward an Arizona victory. However, given the Cubs' history of outperforming expectations as underdogs at Chase Field, bettors should approach this game with caution. A close contest is anticipated, with the Diamondbacks likely securing a narrow win. The over/under set at 8.5 runs seems appropriate, given both teams' potential for offensive bursts and pitching uncertainties.

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