Louisville vs Clemson Betting Pick & Prediction – 11/2/2024

The Louisville Cardinals will take on the Clemson Tigers on November 2, 2024, with the Cardinals listed as 10.5 point underdogs. Early betting trends show Louisville with 80% of spread bets, while Clemson has 20%. The total for this ACC matchup has been set at 61.5 points. Don't miss this exciting matchup between these two college football teams. And continue reading so as not to miss our prediction for Louisville vs Clemson from Death Valley.

Louisville Looks to Pass Huge Road Test

The Louisville Cardinals are a respectable 5-3 overall this season and 3-2 in ACC play. They enter Saturday's Louisville vs Clemson matchup coming off of a win, having beaten the Boston College Eagles in their most recent outing. This week, though, Louisville faces a much tougher test on the road as they take on a Clemson team that has yet to lose a home game this year. Louisville's defense will be the key to their chances in this game, as they have allowed over 30 points to Notre Dame, SMU, and Miami in recent contests against quality opponents.

Clemson Aims to Win Seventh In a Row

The Clemson Tigers still have not lost since their season-opening defeat at the hands of the Georgia Bulldogs. The Tigers have won six games in a row, winning them convincingly to get to 6-1 overall and 5-0 in the ACC. The closest home game for Clemson this season was a 17-point win over Virginia in their last outing two weeks ago. Another lopsided win for the Tigers could push them into the top-10 in the rankings once this week is in the books.

Louisville vs Clemson Prediction

Based on the way Clemson has played at home this season, we have no choice but to lay the points with the Tigers in this Louisville vs Clemson contest. The Tigers have not had a home game decided by single-digits yet this year. We don't expect that to change in this game, as Louisville's suspect defense could once again be a problem for them against an upper-echelon team. Look for Clemson to win big and to make a case that they belong in the top-10.

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