The Buffalo Bills and Houston Texans will meet in an AFC matchup with major early-season importance on Sunday, September 13, 2026. The Bills are slight favorites on the road going into this matchup, while the Texans are looking to start their season with a win at home and to make a statement that they could be one of the last teams standing in the AFC this year.
Here, Jay Sanin breaks down this NFL Week 1 game, looking at the keys to the game and making his prediction for the contest. Will Josh Allen and the Bills get an impressive road win, or will CJ Stroud and Houston hold serve on their home turf?
Before kickoff, be sure to check out our full Bills vs Texans prediction for more information on this key contest from Reliant Stadium.
