Denver Broncos vs Philadelphia Eagles Prediction - 10/5/2025
Updated September 30, 2025
Updated September 30, 2025
The Denver Broncos will take on the defending champion Philadelphia Eagles in Week 5 of the NFL season. Denver snapped a two-game losing streak in their last game and will try to get their first road win of the season in one of the toughest places to play in the NFL. Before kickoff from Philadelphia, continue reading to get my Broncos vs Eagles prediction for Sunday.
Odds | |
|---|---|
Spread | Eagles –3.5 |
Moneyline | Broncos +170, Eagles –200 |
Total | Over/Under 43.5 |
Bo Nix has shown flashes of dual-threat ability for the Broncos. He has seven touchdown passes and four interceptions on the season. He will be tested by Philadelphia’s defensive speed, especially if they can still generate pressure despite injuries.
Jalen Hurts has a high floor for the Eagles. He hasn't thrown an interception yet this season and has piled up the rushing touchdowns early in the year as well. Denver has a very good defense, but the poise of Hurts is well-documented at this point.
Score Projection: Denver 20 – Philadelphia 24
Win Probability: Denver 36%, Philadelphia 64%
The Broncos have clearly struggled to generate enough offense to win on the road so far this season. Against the best, most physical team in football, I don't see that changing this week. I will lay the points with the Eagles here, as they should be able to lean on the Broncos in the trenches and improve to 5-0 on the year.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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