San Antonio Spurs vs Los Angeles Lakers Prediction – 12/10/2025

The San Antonio Spurs head to Los Angeles to face the Los Angeles Lakers this Wednesday night in the quarterfinals of the 2025 NBA Cup. Both teams are in the top five in the Western Conference standings this season and are three wins away from lifting this year’s NBA Cup. Who will advance at Crypto.com Arena on Wednesday night? Continue reading to get my Spurs vs Lakers prediction from the West Coast.

Our Spurs vs Lakers Pick

Game Snapshot

• Matchup: San Antonio Spurs @ Los Angeles Lakers
• Date & Time: Wednesday, December 10, 2025, 10:00 PM ET
• Venue: Crypto.com Arena, Los Angeles, CA
• Broadcast: Prime Video

Key Storylines

• The Lakers come in as the favorite, with most sportsbooks putting the spread at 4.5 points. Their home-court advantage has been huge this year, as they are 7-3 at home to this point in the 2025-26 NBA season.
• These teams are evenly matched going into this matchup. They are separated by a game in the standings and played a very close game earlier this season, one that the Lakers won at home. We could see another game that goes down to the wire between these squads, which would be even more entertaining given everything that is on the line in the NBA Cup.
• The Spurs, meanwhile, are fighting through some roster issues. Their recent 130–117 loss to the Cleveland Cavaliers was marked by an epic third-quarter collapse, where Cleveland went on a 44–25 run. The absence of big man Victor Wembanyama has been a huge issue, but he is listed as questionable for this contest and his return would be massive for the Spurs.
• The Lakers have NBA Cup experience after winning the first edition of the competition a couple of years ago. They also have championship experience in the NBA Finals through players like LeBron James. All of that could come in handy in an elimination game like this one.

Head-to-Head & Betting Trends

• In their most recent meeting in November, the Lakers defeated the Spurs 118–116 at Crypto.com Arena.
• The Lakers are 15-8 against the spread so far this season.
• San Antonio is 11-10-2 against the spread going into Wednesday’s game.
• The Spurs have gone over the total in 13 of their first 23 games this year.
• The Lakers are 16-7 to the over this year, the highest percentage of overs in the league.

Best Player Props to Watch

Spurs vs Lakers Model Projection

Final Thoughts

Affiliate Disclosure

ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.