Philadelphia 76ers vs New York Knicks Prediction & Best Bet – 12/19/2025

The Philadelphia 76ers head into Friday night’s game with the New York Knicks trying to make a statement against an Eastern Conference rival. The Knicks have won seven straight games and have been among the top teams in the East this season. They are favored on their home floor at Madison Square Garden. Before tip-off from New York City, you will find my 76ers vs Knicks prediction below.

Our 76ers vs Knicks Pick

Game Snapshot

• Matchup: Philadelphia 76ers @ New York Knicks
• Date & Time: December 19, 2025, 7:00 PM ET
• Venue: Madison Square Garden, New York, NY
• Broadcast: Prime Video

Key Storylines

New York enters this game having won seven straight games and proving difficult to slow down at home. Jalen Brunson has been a consistent scoring force, frequently delivering for the Knicks in clutch moments, including a game-winning trey in their most recent outing against Indiana. That win extended their winning streak and highlighted New York’s ability to find scoring from both stars and bench contributors. The Knicks’ offense has been among the more efficient units in the league this season, and they have shown resilience when games tighten in the fourth quarter.

New York is on the second night of a back-to-back here, and there are some injury questions surrounding their roster going into this matchup. The Knicks were without Karl-Anthony Towns, Josh Hart, and Mitchell Robinson last night. They could return tonight, but that is not a guarantee.

Philadelphia faces its own uncertainty. While Tyrese Maxey remains a primary scoring option, his recent illness has clouded his availability and may impact his performance or minutes. Joel Embiid is also listed as day-to-day with an illness, raising questions about his effectiveness. With multiple players on the 76ers’ injury list, their depth could be tested, particularly against a Knicks squad that has shown depth and balance. The health of Maxey and Embiid will be key leading up to tipoff.

Head-to-Head & Betting Trends

• This is the first of four regular-season games between the Knicks and Sixers this season.
• The Knicks are 18-9 against the spread this season, the best ATS record in the league.
• Philadelphia is 15-10 against the spread entering this matchup.
• Philadelphia has gone under the total in 13 of their 25 games this season.
• New York is 15-12 to the over so far this year.

Best Player Props to Watch

76ers vs Knicks Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.