Philadelphia 76ers vs Cleveland Cavaliers Prediction - 11/5/2025
Updated November 5, 2025
Updated November 5, 2025
The Cleveland Cavaliers will host the Philadelphia 76ers on Wednesday night in an important Eastern Conference contest in the NBA. The Sixers are playing on the second night of a back-to-back here and will have to overcome some roster concerns that go along with that. Cleveland will try to take advantage of the Sixers' tired legs on their home floor. Before tip-off from Cleveland, you can find my 76ers vs Cavaliers prediction below.
Player | Prop to consider |
|---|---|
Tyrese Maxey (76ers) | Over 31.5 points |
Donovan Mitchell (Cavaliers) | Over 25.5 points |
Jarrett Allen (Cavaliers) | Over 8.5 rebounds (if he plays) |
Score Projection: Philadelphia 112 – Cleveland 125
Win Probability: Philadelphia 35%, Cleveland 65%
The Cavaliers should enjoy a breakout performance at home tonight against a Sixers team playing for the second night in a row. Embiid will likely be out of the Philly lineup, allowing the duo of Allen and Mobley to dominate the glass. That should allow Cleveland all of the chances they need to put up a ton of points and cover the spread as a double-digit favorite.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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